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Showing 1 - 6 of 6 matches in All departments

Analogue-based Drug Discovery II (Hardcover): Janos Fischer, C. Robin Ganellin Analogue-based Drug Discovery II (Hardcover)
Janos Fischer, C. Robin Ganellin
R4,152 R3,367 Discovery Miles 33 670 Save R785 (19%) Shipped within 7 - 12 working days

Born out of a project of the IUPAC's committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog classes and eight case studies. Like its precursor, this volume also contains a general section discussing universally applicable strategies for analog discovery and development. Spanning a wide range of therapeutic fields and chemical classes, the two volumes together constitute the first systematic approach to drug analog development.
Of interest to virtually every researcher working in drug discovery and pharmaceutical chemistry.

Successful Drug Discovery (Hardcover, Volume 4): Janos Fischer, Christian Klein, Wayne E Childers Successful Drug Discovery (Hardcover, Volume 4)
Janos Fischer, Christian Klein, Wayne E Childers
R3,421 R2,396 Discovery Miles 23 960 Save R1,025 (30%) Shipped within 7 - 13 working days
Analogue-based Drug Discovery III (Hardcover): Janos Fischer, C. Robin Ganellin, David P. Rotella Analogue-based Drug Discovery III (Hardcover)
Janos Fischer, C. Robin Ganellin, David P. Rotella
R3,326 R2,684 Discovery Miles 26 840 Save R642 (19%) Shipped within 7 - 12 working days

Most drugs are analogue drugs. There are no general rules how a new drug can be discovered, nevertheless, there are some observations which help to find a new drug, and also an individual story of a drug discovery can initiate and help new discoveries. Volume III is a continuation of the successful book series with new examples of established and recently introduced drugs.
The major part of the book is written by key inventors either as a case study or a study of an analogue class. With its wide range across a variety of therapeutic fields and chemical classes, this is of interest to virtually every researcher in drug discovery and pharmaceutical chemistry, and -- together with the previous volumes -- constitutes the first systematic approach to drug analogue development.

Successful Drug Discovery (Hardcover, Volume 2): Janos Fischer, Wayne E Childers Successful Drug Discovery (Hardcover, Volume 2)
Janos Fischer, Wayne E Childers
R2,886 R2,286 Discovery Miles 22 860 Save R600 (21%) Shipped within 7 - 12 working days

Retaining the successful approach found in the previous volume in this series, the inventors and primary developers of drugs that successfully made it to market tell the story of the drug's discovery and development and relate the often twisted route from the first candidate molecule to the final marketed drug. 11 selected case studies describe recently introduced drugs that have not been previously covered in textbooks or general references. These range across six different therapeutic fields and provide a representative cross-section of the current drug development efforts. Backed by copious data and chemical information, the insight and experience of the contributors makes this one of the most useful training manuals that a junior medicinal chemist can hope to find and has won the support and endorsement of IUPAC.

Successful Drug Discovery (Hardcover, Volume 1): Janos Fischer, David P. Rotella Successful Drug Discovery (Hardcover, Volume 1)
Janos Fischer, David P. Rotella
R2,879 R2,279 Discovery Miles 22 790 Save R600 (21%) Shipped within 7 - 12 working days

The first volume of the book series "Successful Drug Discovery" is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds: small-molecule-, peptide-, and protein-based drugs. The role of serendipity is analyzed in some very successful drugs where the research targets of the lead molecule and the drug are different. Phenotypic and target-based drug discovery approaches are discussed from the viewpoint of pioneer drugs and analogues. This volume gives an excellent overview of insulin analogues including a discussion of the properties of rapid-acting and long-acting formulations of this important hormone. The major part of the book is devoted to case histories of new drug discoveries described by their key inventors. Eight case histories range across many therapeutic fields. The goal of this book series is to help the participants of the drug research community with a reference book series and to support teaching in medicinal chemistry with case histories and review articles of new drugs.

Analogue-based Drug Discovery (Hardcover): IUPAC (International Union of Pure and Applied Chemistry), Janos Fischer, C. Robin... Analogue-based Drug Discovery (Hardcover)
IUPAC (International Union of Pure and Applied Chemistry), Janos Fischer, C. Robin Ganellin
R5,938 R4,139 Discovery Miles 41 390 Save R1,799 (30%) Shipped within 7 - 13 working days

The first authoritative overview of past and current strategies for successful drug development by analog generation, this unique resource spans all important drug classes and all major therapeutic fields, including histamine antagonists, ACE inhibitors, beta blockers, opioids, quinolone antibiotics, steroids and anticancer platinum compounds.

Of the 19 analog classes presented in detail, 9 are described by the scientists who discoverd them.

The book includes a table of the most successful drug analogs as based on the IMS ranking and compares them in terms of chemical structure, mode of action and patentability.

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