MASTER MODERN MEDICINE! Introducing the Landmark Twentieth Edition of the Global Icon of Internal MedicineThe definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison's Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible. Essential for practice and education, the landmark 20th Edition features: Thoroughly revised content-covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison's. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care. State-of-the-art coverage of disease mechanisms: Harrison's focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison's summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system's role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals. All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine- Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine. Important and timely new chapters-such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more-offer the very latest, definitive perspectives on must-know topics in medical education and practice. Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes. End-of-chapter suggested readings reinforc

Based on the popular review course from Harvard Medical School, The Brigham Intensive Review of Internal Medicine Question & Answer Companion, 2nd Edition, provides more than 450 questions and in-depth answers on all specialties of internal medicine, as well as palliative care, occupational medicine, psychiatry, and geriatric medicine. Ideal for preparing for certification or maintenance of certification, this highly regarded review tool positions you for exam success! Shares the knowledge and expertise of leading authorities from Harvard as well as former chief residents at Brigham and Women's Hospital. Contains 450+ board review style questions with full discursive responses - all extensively revised to reflect current board standards. Features a brand new, full-color design with all-new diagrams and color photos. Provides thoroughly revised information throughout, with many new figures and updated tables. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

With authoritative coverage of everything from recent discoveries in the field of vascular biology to recent clinical trials and evidence-based treatment strategies, Vascular Medicine, 3rd Edition, is your go-to resource for improving your patients' cardiovascular health. Part of the Braunwald family of renowned cardiology references, this updated volume integrates a contemporary understanding of vascular biology with a thorough review of clinical vascular diseases, making it an ideal reference for vascular medicine specialists, general cardiologists, interventional cardiologists, vascular surgeons, and interventional radiologists. Incorporates technologic advances in vascular imaging - including ultrasound, MRI, CTA, and catheter-based angiography - along with more than 230 new figures, providing an up-to-date and complete view of the vascular system and vascular diseases. Covers novel antithrombotic therapies for peripheral artery disease and venous thromboemboism, advances in endovascular interventions for aortic aneurysms, and today's best surgical treatments for vascular diseases. Includes seven new chapters: Pathobiology of Aortic Aneurysms; Pathobiology and Assessment of Cardiovascular Fibrosis; Large Vessel Vasculitis; Medium and Small Vessel Vasculitis; Epidemiology and Prognosis of Venous Thromboembolic Disease; Fibromuscular Dysplasia; and Dermatologic Manifestations of Vascular Disease. Discusses methods for aggressive patient management and disease prevention to ensure minimal risk of further cardiovascular problems. Keeps you current with ACC/AHA and ECC guidelines and the best ways to implement them in clinical practice. Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

Pulmonary and Critical Care Medicine - as only Harrison's can cover it Featuring a superb compilation of chapters related to pulmonary and critical care topics derived from Harrison's Principles of Internal Medicine, Nineteenth Edition (including content from the acclaimed Harrison's DVD, now available here in print), this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined Harrison's. You will find 45 chapters from more than 70 renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation. Features: * Logically divided into five sections that reflect the scope of pulmonary and critical care medicine: Diagnosis of Respiratory Disorders, Diseases of the Respiratory System, General Approach to the Critically Ill Patient, Common Illnesses and Syndromes, and Disorders Complicating Critical Illnesses and Their Management * Integration of pathophysiology with clinical management * High-yield board review questions make this text ideal for keeping current or preparing for the boards * Valuable appendix of laboratory values of clinical importance

Cardiovascular Medicine - with all the authority of Harrison's Featuring a superb compilation of chapters related to cardiovascular medicine derived from Harrison's Principles of Internal Medicine, Nineteenth Edition (including content from the acclaimed Harrison's DVD, now available here in print), this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined Harrison's. You will find 53 chapters from 58 renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation. Features: * Current, complete coverage of essential cardiovascular medicine topics, including Diagnosis of Cardiovascular Disorders, Heart Rhythm Disturbances, Disorders of the Heart, and Disorders of the Vasculature * An important opening section "Introduction to Cardiovascular Disorders" provides a systems overview, beginning with the basic biology of the cardiovascular system, followed by epidemiology of cardiovascular systems, and approach to the patient * Integration of pathophysiology with clinical management * High-yield board review questions make this text ideal for keeping current and preparing for the boards * Helpful appendix of laboratory values of clinical importance

Based on the popular review course from Harvard Medical School, The Brigham Intensive Review of Internal Medicine, 3rd Edition, provides in-depth coverage on all specialties of internal medicine, as well as palliative care, occupational medicine, psychiatry, and geriatric medicine. Ideal for preparing for certification or recertification, this highly regarded review tool keeps you up to date with tremendous changes in the field, incorporating detailed discussions in every chapter, essential learning points, more than 600 review questions, numerous tables and figures, and more. Organizes 100+ chapters into 10 broad sections, with one additional section devoted to board simulation. Each chapter includes a section of multiple-choice questions. Shares the knowledge and expertise of leading authorities from Harvard as well as former chief residents at Brigham and Women's Hospital, making this an excellent exam review tool as well as a general practice resource. Includes three new chapters: Sedation Agitation-Sleep Deprviation; Hepatitis B and C; and Evaluation of the Dyspneic Patient. Features a brand new, full-color design with all-new diagrams and color photos. Provides extensively revised information throughout, including more MOC-focused content. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. Network Medicine introduces this rapidly evolving field of medical research, which promises to revolutionize the diagnosis and treatment of human diseases. With contributions from leading experts that highlight the necessity of a team-based approach in network medicine, this definitive volume provides readers with a state-of-the-art synthesis of the progress being made and the challenges that remain. Medical researchers have long sought to identify single molecular defects that cause diseases, with the goal of developing silver-bullet therapies to treat them. But this paradigm overlooks the inherent complexity of human diseases and has often led to treatments that are inadequate or fraught with adverse side effects. Rather than trying to force disease pathogenesis into a reductionist model, network medicine embraces the complexity of multiple influences on disease and relies on many different types of networks: from the cellular-molecular level of protein-protein interactions to correlational studies of gene expression in biological samples. The authors offer a systematic approach to understanding complex diseases while explaining network medicine's unique features, including the application of modern genomics technologies, biostatistics and bioinformatics, and dynamic systems analysis of complex molecular networks in an integrative context. By developing techniques and technologies that comprehensively assess genetic variation, cellular metabolism, and protein function, network medicine is opening up new vistas for uncovering causes and identifying cures of disease.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Nothing prepares you for exam success like Harrison's! VIBRANT FULL-COLOR PRESENTATION INCLUDES COLOR ATLAS -- 500 ALL-NEW QUESTIONS! Now you can add the unmatched authority of Harrison's to your board review or test preparation. Based on the content of Harrison's Principles of Internal Medicine, Nineteenth Edition, this rigorous study aid is essential for Internal Medicine Board certification or recertification/maintenance of certification, or as a refresher for any internal medicine examination. Reflecting the accuracy, currency, and wide scope of Harrison's, this complete review of internal medicine delivers more than 1,000 extremely challenging review questions, many of which utilize realistic patient scenarios, including radiographic and pathologic images. Each question is accompanied by explanations for correct and incorrect answers. These explanations -- which are derived from and cross-referenced to Harrison's Principles of Internal Medicine, Nineteenth Edition - are one of the most effective ways to learn and teach internal medicine. They are designed to bolster your understanding of pathophysiology, epidemiology, differential diagnosis, clinical decision making, and therapeutics. The format of the book has also been enhanced, allowing for a more effective use of color images throughout. Readers will appreciate the convenience of having color images next to their citations in the text. A GREAT WAY TO LEARN INTERNAL MEDICINE: * Coverage spans the entire spectrum of internal medicine * Each topic is covered in proportion to its level of importance on the Internal Medicine Examination Blueprint * Approximately 500 NEW, never-before-published Q&As (more than 60% of the questions are NEW!) * Includes full-color atlas * Content follows the organization of Harrison's Principles of Internal Medicine, Nineteenth Edition - making it perfect for side-by-side study * Beautiful full-color presentation

Nephrology and Acid-Base Disorders - with all the authority of Harrison's Featuring a superb compilation of chapters related to nephrology and acid-base disorders derived from Harrison's Principles of Internal Medicine, Nineteenth Edition (including content from the acclaimed Harrison's DVD, now available here in print), this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined Harrison's. You will find 23 chapters from 45 renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation. FEATURES * Content reflects the full scope of nephrology * Valuable opening sections provides a systems overview, covering renal development, function, and physiology, and provides an overview of how the kidney responds to injury * Complete coverage of essential topics such as acidosis and alkalosis, fluid and electrolyte disorders, and hypercalcemia * Integration of pathophysiology with clinical management * High-yield board review questions make this text ideal for keeping current and preparing for the boards * Helpful appendix of laboratory values of clinical importance

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. All the authority of the most trusted brand in medical content in a convenient, portable guide The Harrison's Manual, derived from most clinically salient content featured in Harrison's Principles of Internal Medicine, 20th Edition, delivers numerous clinical algorithms in one practical, portable resource. The Manual also includes abundant quick reference tables, plus concise text-providing rapid access to bedside information when decisions need to be made quickly. This full color summary guide covers all diseases and conditions commonly seen in inpatient general medicine, so you can be sure to find invaluable content directly to your workflow and practice. The 20th edition has been updated to reflect the latest clinical developments in medicine. The Manual truly makes it easy to find what you need at the point of care. The easy-to-navigate chapters cover symptoms/signs, medical emergencies, specific diseases, and care of the hospitalized patient, with a particular focus on: *Etiology and Epidemiology *Clinically Relevant Pathophysiology *Signs and Symptoms *Differential Diagnosis *Physical and Laboratory Findings *Therapeutics *Practice Guidelines, and more

This fully revised and updated new edition provides a comprehensive look at nitrite and nitrate and their effect on human health and disease. The first section describes the biochemical analysis of nitrite and nitrate and its role in human physiology. The book then shifts to sources of human exposure of nitrite and nitrate, including environmental and dietary. Finally, the last section discusses nitric oxide-based therapeutics and how nitrite and nitrate biochemistry can be safely harnessed to improve human health. Each chapter provides a balanced, evidence-based view and heavily cites the most recent published literature. They follow a strict chapter format which includes keywords, key points, a conclusion highlighting major findings, and extensive references. The second edition contains new chapters on nitrite and nitrate in age medicine, nitrite and nitrate as a treatment for hypertension, and nitrite and nitrate in exercise performance. Additionally, the editors have expanded the biochemistry section to include chapters on nitrate reducing oral bacteria, nitrite mediated S-Nitrosation, epigenetics and the regulation of nitric oxide, and nitrite control of mitochondrial function. Nitrate and Nitrite in Human Health and Disease, 2e, will be of interest to health professionals, nutritionists, dieticians, biomedical scientists, and food scientists.

This fully revised and updated new edition provides a comprehensive look at nitrite and nitrate and their effect on human health and disease. The first section describes the biochemical analysis of nitrite and nitrate and its role in human physiology. The book then shifts to sources of human exposure of nitrite and nitrate, including environmental and dietary. Finally, the last section discusses nitric oxide-based therapeutics and how nitrite and nitrate biochemistry can be safely harnessed to improve human health. Each chapter provides a balanced, evidence-based view and heavily cites the most recent published literature. They follow a strict chapter format which includes keywords, key points, a conclusion highlighting major findings, and extensive references. The second edition contains new chapters on nitrite and nitrate in age medicine, nitrite and nitrate as a treatment for hypertension, and nitrite and nitrate in exercise performance. Additionally, the editors have expanded the biochemistry section to include chapters on nitrate reducing oral bacteria, nitrite mediated S-Nitrosation, epigenetics and the regulation of nitric oxide, and nitrite control of mitochondrial function. Nitrate and Nitrite in Human Health and Disease, 2e, will be of interest to health professionals, nutritionists, dieticians, biomedical scientists, and food scientists.

Nitrite and Nitrate in Human Health and Disease delivers a comprehensive review of nitrite and nitrate biology, from basic biochemistry to the complex physiology and metabolism of these two naturally occurring molecules in the human body. Well-organized and well referenced chapters cover the rich history of nitrite and nitrate, sources of exposure, and the physiological effects when consumed through foods containing nitrite and nitrate. The chapters are written by leading experts, all of whom share their research and perspectives in order to help define the context for benefits vs. any potential risks associated with nitrite and nitrate use, either through dietary ingestion or therapeutic dosing. This diverse collection of authors includes vascular biologists, physiologists, physicians, epidemiologists, cancer biologists, registered dieticians, chemists, and public health experts from five countries in both academia and government. Nitrite and Nitrate in Human Health and Disease provides a balanced view of nitric oxide biochemistry, and nitrite and nitrate biochemistry in physiology and in the food sciences.

When Maria Velasquez began to hear the thoughts of others, she knew life would never be the same; but the possibility she could be the savior of not only the world, but an entire galaxy had never crossed her mind. Now Maria finds herself on a journey of self-discovery that takes her from the suburbs of Manhattan to a planet buried deep in the subgalaxy. Maria's guide on her journey is Wynn, the descendant of Paladins sent here to protect Earth from the impending danger posed by the evil Czar Caiphas, leader of the Galactic Socialist Regime. Their mission is to watch and wait for an earthling to emerge whom they believe could be the Heir to Master Suuth, an ancient Master of the Paladins secreted to our world to protect him from the Czar. Accessible through a rift in space, a phenomenon of light and gravity known as the Cold Star, the subgalaxy is a realm ruled by the opposing forces of magic and faith. Ripe with political intrigue and a never-ending state of galactic war, the clashing of our two galaxies promises an explosive result. Can Wynn and Maria unlock the secrets of the Master's Heir and defeat Czar Caiphas and his Knights? Cold Star is a fast-paced futuristic Galactic Fantasy certain to transport you through time and space and leave you wanting more.

Leading clinical and experimental investigators comprehensively review the chemistry, biochemistry, molecular biology, physiology, and pathophysiology of nitric oxide in the cardiovascular systems. These experts particularly illuminate nitric oxide biology, its cardiovascular pathophysiology, and its role in cardiovascular therapeutics. Topics also included are the development of nitric oxide donors for the treatment of myocardial ischemia and thrombosis, the development of gene therapeutic restoration of endothelial function in atherosclerosis, and the application of nitric oxide biology to investigative arenas in cardiovascular medicine. With its balanced presentation of basic and clinically relevant information, Nitric Oxide and the Cardiovascular System provides a comprehensive, authoritative guide for all those cardiovascular biologists, cardiologists, physiologists, and cardiovascular surgeons engaged in today's clinical or experimental research.

Based upon the popular review course from Harvard Medical School, The Brigham Intensive Review of Internal Medicine is a comprehensive study guide for the American Board of Internal Medicine certification or maintenance of certification examination as well as for general practice review by physicians and residents. This authoritative, thorough resource provides in-depth coverage on all specialties of internal medicine, as well as palliative care, occupational medicine, psychiatry, and geriatric medicine. Editors Ajay K. Singh and Joseph Loscalzo recruited leading authorities from Harvard as well as former chief residents at Brigham and Women's Hospital to contribute to this book. Featuring over 600 board review questions, with numerous tables and figures, chapters offer detailed discussions with emphasis on essential learning points. Over 100 chapters are organized into 10 broad sections, with one additional section dedicated to board simulation. As the required content for the American Board of Internal Medicine continues to evolve, studying can prove challenging. The Brigham Intensive Review of Internal Medicine is the ideal study guide for anyone preparing for certification or recertification.

Leading clinical and experimental investigators comprehensively review the chemistry, biochemistry, molecular biology, physiology, and pathophysiology of nitric oxide in the cardiovascular systems. These experts particularly illuminate nitric oxide biology, its cardiovascular pathophysiology, and its role in cardiovascular therapeutics. Topics also included are the development of nitric oxide donors for the treatment of myocardial ischemia and thrombosis, the development of gene therapeutic restoration of endothelial function in atherosclerosis, and the application of nitric oxide biology to investigative arenas in cardiovascular medicine. With its balanced presentation of basic and clinically relevant information, Nitric Oxide and the Cardiovascular System provides a comprehensive, authoritative guide for all those cardiovascular biologists, cardiologists, physiologists, and cardiovascular surgeons engaged in today's clinical or experimental research.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. CELEBRATING THE HISTORY OF AMERICA'S LANDMARK INSTITUTIONThe fascinating true story of Brigham and Women's Hospital Founded in 1913, the Peter Bent Brigham Hospital was the first medical institution since John Hopkins to foster clinical clerkships of medical students in the environment of a modern residency program. Forging a partnership with Harvard Medical School, the Brigham would become a major innovator in clinical research, implementing a new educational model that would inspire other hospitals for generations to come. In 1980 the Brigham merged with two other Boston medical institutions boasting their own profoundly important histories, the Boston Hospital for Women and the Robert Breck Brigham Hospital, to become Brigham and Women's Hospital (BWH). This rich and insightful account brings this remarkable story to life: the milestone achievements, medical breakthroughs, and personal dedication that have made BWH a world-class leader in academic medicine. The Teaching Hospital includes: A comprehensive history of BWH, from its continued commitment to medicine, education, and compassionate care to its ongoing leadership in transforming science-driven healthcare today. A compendium of BWH's famous firsts, including the nation's first maternity ward, the first in-vitro fertilization, the first successful human organ transplant, New England's first coronary care unit, and most recently, the first full-face transplant, as well as cutting-edge research in stem cells, systems biology, and bioengineering. A celebration of Brigham's luminaries and landmarks, from pioneers like Dr. Harvey Cushing, the father of modern neurosurgery, Dr. Bernard Lown, Nobel Peace Prize winning cardiologist, and Paul Farmer, co-founder of Partners in Health, to the hospital's milestone breakthroughs in radiology, arthritis, transplant surgery, immunology, women's health, community health, and more. With invaluable contributions from medical historians and doctors, this essential volume provides an in-depth history of the institution. Here is the evolution of BWH in all its dimensions: its reputation as an education and clinical innovator, its role in fostering groundbreaking biomedical research, its ties to the local community as well as to the nation and the world, its financial and administrative growth across the decades, the personalities who have made BWH famous, and the fascinating inner life of the hospital. Filled with stories of profound commitment, critical analysis, and behind-the-scenes details, the book celebrates the Brigham's history in both a medical and cultural context.

SPECIAL OFFER! SAVE WHEN YOU PURCHASE HARRISON'S PRINCIPLES OF INTERNAL MEDICINE SELF-ASSESSMENT AND BOARD REVIEW ALONG WITH THE COMPANION HARRISON'S MANUAL This dollar-saving Harrison's bundle includes two great resources: Harrison's Principles of Internal Medicine Self-Assessment and Board ReviewBased on the content of Harrison's Principles of Internal Medicine, Nineteenth Edition, this full-color study aid is essential for Internal Medicine Board certification or recertification/maintenance of certification, or as a refresher for any internal medicine examination. Reflecting the accuracy, currency, and wide scope of Harrison's, this complete review of internal medicine delivers more than 1,000 extremely challenging review questions, many of which utilize realistic patient scenarios, including radiographic and pathologic images. Each question is accompanied by explanations for correct and incorrect answers. These explanations -- which are derived from and cross-referenced to Harrison's Principles of Internal Medicine, Nineteenth Edition - are one of the most effective ways to learn and teach internal medicine. They are designed to bolster your understanding of pathophysiology, epidemiology, differential diagnosis, clinical decision making, and therapeutics. You will also find a beautiful full-color atlas. The package also includes..... Harrison's Manual of Medicine, Nineteenth Edition Harrison's Manual of Medicine is a concise, bedside resource derived from content found in Harrison's Principles of Internal Medicine, Nineteenth Edition. Perfect for use at the point of care, the Manual presents clinical information covering key aspects of the diagnosis, clinical manifestations, and treatment of the major diseases that are likely to be encountered in medical practice.Presented in full color and incorporating an efficient blend of succinct text, bullet points, algorithms, and tables Harrison's Manual of Medicine, Nineteenth Edition covers every area of clinical medicine, including:* Etiology and Epidemiology* Clinically Relevant Pathophysiology* Signs and Symptoms* Differential Diagnosis* Physical and Laboratory Findings* Therapeutics* Practice Guidelines

As the number of patients with thrombosis and thrombolysis increases, there is a critical need for clinicians to learn the latest scientific discoveries and treatment options. This timely Third Edition is a comprehensive text for cardiologists, hematologists, and pharmacologists in need of a resource on current agent development technology for treating cardiovascular and thromboembolic diseases.

New to the Third Edition

• a thorough examination of all the agents involved in treating thrombosis
• chapters on biomarkers, testing, and pharmacogenomics
• key topics, including new targets for antithrombotics, the development of novel classes of platelet inhibitors, new thrombolytic therapies, and evolving clinical uses of thrombolytics for ischemic stroke and venous thrombosis
• the hemostatic and thrombotic pathways

A better understanding of the pathophysiology of renal failure coupled with technological advances in dialysis techniques and renal transplantation have greatly improved the prognosis and survival for patients with end-stage renal disease (ESRD). Unfortunately, the advances and success of treatment are limited by a number of extrarenal complications that can cause significant morbidity and mortality. Of these, cardiovascular abnormalities are the most common, with cardiac complications alone accounting for more than 40% of deaths in international registries. The importance of cardiovascular complications has become more apparent in recent years with the increased prevalence of diabetes mellitus and vascular nephropathy and with the general ageing of patients with ESRD. The past decade has witnessed enormous advances in understanding the causes and pathophysiology of cardiovascular disease, and their diagnosis, treatment, and prevention. It is, therefore, of importance for physicians caring for patients with end- stage renal failure to understand the pathogenesis of cardiovascular complications, to become familiar with modern diagnostic tools and techniques, and to recognise and treat these complications. The goal of this text is to provide a comprehensive review of the pathophysiology and clinical manifestations of the principal cardiovascular complications in patients with chronic renal failure. The text is intended to assist nephrologists, cardiologists, and internists who care for these patients. The book includes nineteen chapters and is organised in three parts. The first includes three chapters dealing with the epidemiology of cardiovascular disease in patients with end-sage renal failure. The second comprises eight chapters on the basic pathophysiology and pathobiology of cardiovascular diseases in the setting of end- stage renal failure. The third includes eight chapters focussing on clinical manifestations and diagnosis of cardiovascular disease in patients with end-stage renal failure and their management.