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This authoritative new book provides a comprehensive overview of diagnostic and therapeutic strategies in hematopoietic cell transplantation, explaining key concepts, successes, controversies and challenges. The authors and editors discuss current and future strategies for major challenges, such as graft-versus-host-disease, including new prophylaxis and treatments. They also discuss long-term complications, such as second malignancies and cardiovascular complications. Chapters are written by leading world experts, carefully edited to achieve a uniform and accessible writing style. Each chapter includes evidence-based explanations and state-of-the-art solutions, providing the reader with practice-changing advice. Full reference lists are also supplied to facilitate further exploration of each topic. Each copy of the printed book is packaged with a password, giving readers online access to all text and images. This inspiring resource demystifies both the basics and subtleties of hematopoietic cell transplantation, and is essential reading for both senior clinicians and trainees.
This is an essential guide to the data, basic science, outcome studies and decision-making processes involved in blood and marrow stem cell transplantation. Organized according to disease types and procedures, it contains more than 100 tables, figures and algorithms that reflect up-to-date research and give guidance on the choices between different types of chemotherapy, autologous vs. allogeneic transplantation, peripheral blood vs. bone marrow stem cells, and standard vs. experimental treatments. This new edition summarizes the research of the last four years and gives mature data for all established indications, such as acute myeloid leukemia, myelodysplastic syndrome and Hodgkin and non-Hodgkin lymphomas. New chapters discuss global trends in stem cell transplantation, cellular therapies including donor lymphocytes, and pediatric neurologic and metabolic disorders. With an expanded complications section, links to electronic databases and discussion of new drugs and alternative stem cell sources, this text belongs in every transplant unit.
The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues. Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues Written and edited by leaders in the field The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine. About the Author Kerry Atkinson, MBBS MD DTM&H FRCP FRACP, is an Adjunct Professor at the University of Queensland Centre for Clinical Research in Brisbane, Australia, an Adjunct Professor in the Stem Cell Laboratories, Queensland University of Technology at the Translational Research Institute, Brisbane, Queensland, Australia and a Specialist in Internal Medicine at the Salisbury Medical Centre, Brisbane, Queensland, Australia.
This is an easy-to-read comprehensive book on birds covering all aspects of bird behavior including the number of bird species, endemic bird species, the classification of birds, extinct birds, eating and drinking, feathers and plumage, grooming and preening, eyesight, hearing, sense of smell, bills and beaks, feet, types of vocalization, non-vocal communication, types of flight, hunting techniques, courtship and mating, territories, nesting, migration, intelligence and learning, collective nouns for groups of birds of the same species, answers to commonly asked questions about birds (commonest, fastest, heaviest and so on), a section on who was that bird named after, and a final section on some intriguing bird names like the Kagu and the Melancholy Woodpecker. It is also the first bird book to show links between birds and paintings by Velasquez and Constable, Bob Dylan, TS Eliot, Shelley and even Lamborghini sports cars. Illustrated with over 300 color photographs, this bird book tells you everything you wanted to know about these miraculous creatures
Bone marrow transplantation (BMT) has become a leading treatment world wide for a variety of cancers, including breast and testicular cancer in addition to leukemias and other haematological cancers. The BMT Data Book serves as a reference to aid the often complex decision-making process confronting clinicians. Organized according to disorder, hundreds of tables, lists and figures summarize data necessary to grasp transplantation therapy for leukaemia, lymphoma, aplastic anaemia, breast cancer, testicular cancer and other malignancies. For each, clinical outcomes are compared between transplant and non-transplant therapies. Additional sections outline procedures, cytotoxic drug regimes, basic science and laboratory medicine. A concise, comprehensive manual, The BMT Data Book will provide a unique reference tool for all clinicians involved in bone marrow or blood cell transplantation. It may be used as a companion to Clinical Bone Marrow Transplantation (Cambridge University Press, 1994) edited by Kerry Atkinson.
This second edition has been completely updated and greatly expanded to include detailed information on all aspects of autologous and allogeneic haematopoietic stem cell transplantation. The text builds on the strengths of its first edition by maintaining a balance between detailed scientific explanations and practical information on patient care. Thoroughly referenced through 1999, it is divided into 13 sections, ranging from biological background and practical procedures, to clinical results, major transplant-related and organ-specific problems, laboratory services, and developing areas. This new edition provides an increased emphasis on immune cell therapy and contains over 1,200 figures and tables. The author has enlisted an international list of experts to contribute to this authoritative, user-friendly, practical and well-balanced text. Haematologists, oncologists, transplant specialists, and researchers should find it a useful resource.
The BMT Data Book is an essential guide to the data, outcome studies and complex decision-making processes involved in blood and marrow stem cell transplantation. Organized according to types of diseases and procedures, it contains more than hundred tables, figures and algorithms that reflect up-to-date research and give guidance on the choices between stem cell versus bone marrow transplantation, autologous versus allogeneic transplantation, and conventional versus experimental treatments. This new edition summarizes research of the last 5 years and gives mature data for all established indications, such as acute myeloid leukemia, myelodysplastic syndromes, Hodgkin's and Non-Hodgkin's lymphomas. In addition, controversies and new indications - like renal cell cancer and autoimmune disorders - are discussed plus new drugs and therapies, new stem cell sources (cord blood), new transplant protocols (reduced-intensity conditioning), and a guide to electronic databases.
International expertise in the rapidly developing field of bone marrow transplantation has been collected to provide a balanced overview of both the scientific basis and clinical practice of marrow transplantation. The early chapters dealing with biological background are followed by information relating to the practicalities of transplantation and a comprehensive review of clinical results from an extensive range of disease and graft match situations. Complications are discussed including graft-versus-host disease, infections, organ specific problems, disease recurrence and psychological reactions. The final chapters review such latest developments in the field as the role of novel antileukemic agents, haemopoietic growth factors and monoclonal antibodies. A uniquely detailed and complete reference text, this book will commend itself both to laboratory scientists and clinicians from many specialities, whether they are directly involved in carrying out marrow transplantation procedures or advising on pre and post transplant management and support.
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