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Showing 1 - 18 of 18 matches in All departments

Computational Systems Pharmacology and Toxicology (Hardcover): Rudy J. Richardson Computational Systems Pharmacology and Toxicology (Hardcover)
Rudy J. Richardson; Edited by (editors-in-chief) Diana Anderson; Series edited by Tim Marrs; Translated by Michael D Waters; Contributions by Dale E Johnson, …
R4,644 Discovery Miles 46 440 Ships in 10 - 15 working days

This book will be important for scientists involved in environmental research particularly in filling data gaps for risk assessment. It also will highlight key methods used in studying biological targets both from a toxicity standpoint and pharmacological activity. It provides a systems pharmacology/toxicology approach to computational toxicology, linking chemical exposures to genes, diseases, and complex biological/disease pathways. It also provides the discussion of new approaches to study chemical such as biological target elucidation and move this into computational models. Overall the book expands the computational focus of chemicals and biological interactions into the field of herbal and traditional medicines. It is noteworthy that the book reaches beyond pharmaceutical toxicology. The book will be a useful academic course book for both graduate and undergraduates studying pharmacology. It applies to areas such as Computational Toxicology; Systems biology; chemical-protein interactions; Interactions between Traditional Chinese Medicines/herbal medicines and Western therapeutics. Cross-promote this book with Big Data in Predictive Toxicology.

Toxicogenomics in Predictive Carcinogenicity (Hardcover): Michael D Waters, Russell S. Thomas Toxicogenomics in Predictive Carcinogenicity (Hardcover)
Michael D Waters, Russell S. Thomas; Edited by (editors-in-chief) Diana Anderson; Contributions by Michael D Waters, Luoping Zhang, …
R5,235 Discovery Miles 52 350 Ships in 10 - 15 working days

Toxicogenomics in Predictive Carcinogenicity describes toxicogenomics methods in predictive carcinogenicity testing, mode of action and safety evaluation, and cancer risk assessment. It illustrates these methods using case studies that have yielded significant new information on compounds and classes of compounds that have proven difficult to evaluate using conventional methods alone. This book additionally covers current and potential toxicogenomic research using stem cells as well as new bioinformatics methods for drug discovery and environmental toxicology.The information is needed because it has not previously been available. With the increasing complexity of research in mode of action investigations it is important to gain a better understand of approaches to data integration and health risk assessment. Furthermore, it is essential to consider how novel test systems and newer methods and approaches may be used in future to gain a better understanding of mechanisms. The proposed publication will provide details of chemical case studies not available in previous volumes and will demonstrate how various data is assembled and integrated to arrive at an informed assessment of chemical safety and human health risk. It will be the most current volume which comprehensively covers the subject. This publication is an indispensable tool for postgraduates, academics and industrialists working in biochemistry, genomics, carcinogenesis, pathology, pharmaceuticals, food technology, bioinformatics, risk assessment and environmental toxicology. Societies: American Association for Cancer Research AACR (http://www.aacr.org/) Environmental Mutagenesis and Genomics Society (http://www.emgs/org) International Association of Environmental Mutagen Societies (http://www.iaems/org) International Union of Toxicology (http://www.iutox.org/) Society of Toxicology (http://www.toxicology.org/) Journals for reviews: Cancer Research Mutation Research Toxicology Research Toxicology and Applied Pharmacology Regulatory Toxicology and Pharmacology Toxicology Toxicology Letters Critical Reviews in Toxicology Archives of Toxicology Pharmacology & Toxicology Fundamental and Applied Toxicology Toxicologic Pathology Clinical Toxicology Human and Experimental Toxicology International Journal of Toxicology Toxicology and Industrial Health Drug and Chemical Toxicology Drug safety Journal of Toxicology Toxicological Sciences Websites: American Association for Cancer Research AACR (http://www.aacr.org/) Environmental Mutagenesis and Genomics Society (http://www.emgs/org) International Association of Environmental Mutagen Societies (http://www.iaems/org) International Union of Toxicology (http://www.iutox.org/) Society of Toxicology (http://www.toxicology.org/) Cross-promote with the textbook Fundamental Toxicology

Ecotoxicology and Genotoxicology - Non-traditional Aquatic Models (Hardcover): Michael D Waters, Tim Marrs Ecotoxicology and Genotoxicology - Non-traditional Aquatic Models (Hardcover)
Michael D Waters, Tim Marrs; Edited by (editors-in-chief) Diana Anderson; Contributions by Miguel Santos, N Wagner
R5,238 Discovery Miles 52 380 Ships in 10 - 15 working days

The potential impact of anthropogenic pollutants such as agrochemicals on the environment is of global concern. Increasing use of certain compounds can result in contamination of food, water and atmospheric systems and in order to combat this pollution it is important to be able to accurately monitor the short and long term effects. This book describes the latest aquatic species models used as indicators of the toxic effects of environmental pollutants, including models that have not routinely been used. The book enables understanding of the effects of pollutants in non-target species, and therefore enables analysis of the effects on ecosystems. This book will be of interest to anyone interested in developing new biomarker species with high degrees of ecological relevance. It will serve as a useful resource for regulatory and research toxicologists, particularly those studying freshwater, marine water and sediment environments.

Ecotoxicology and Genotoxicology - Non-traditional Terrestrial Models (Hardcover): Michael D Waters, Tim Marrs Ecotoxicology and Genotoxicology - Non-traditional Terrestrial Models (Hardcover)
Michael D Waters, Tim Marrs; Edited by (editors-in-chief) Diana Anderson; Contributions by N Wagner
R5,313 R4,644 Discovery Miles 46 440 Save R669 (13%) Ships in 10 - 15 working days

The potential impact of anthropogenic pollutants such as agrochemicals on the environment is of global concern. Increasing use of certain compounds can result in contamination of food, water and atmospheric systems and in order to combat this pollution it is important to be able to accurately monitor the short and long term effects. This book describes the latest non-traditional terrestrial species models used as indicators of the toxic effects of environmental pollutants. The book enables understanding of the effects of pollutants in non-target species, and therefore enables analysis of the effects on ecosystems. This book will be of interest to anyone interested in developing new biomarker species with high degrees of ecological relevance. It will serve as a useful resource for regulatory and research toxicologists, particularly those interested in soil screening and the effects of pollutants on wildlife and insects and their use as biological indicators.

Chemical Warfare Toxicology - Complete Set (Hardcover): Horst Thiermann, John Jenner, Franz Worek Chemical Warfare Toxicology - Complete Set (Hardcover)
Horst Thiermann, John Jenner, Franz Worek; Series edited by Michael D Waters, Tim Marrs; Edited by (editors-in-chief) …
R8,724 Discovery Miles 87 240 Ships in 10 - 15 working days

Despite ongoing efforts to prohibit the production, storage and use of chemical warfare agents recent world events highlight the enduring threat to the population from these agents. Research efforts in various countries have resulted in novel insights into chemical warfare toxicology that has enabled the development of new approaches for the diagnosis and treatment of chemical warfare poisoning. This two-volume set provides an up-to-date treatise on the ongoing research into the toxicology of chemical warfare agents, the diagnosis and verification of exposure, and the pre- and post-exposure treatment of poisoning. Focussing on the most important representative nerve and blistering agents, whilst also covering other potential chemical warfare agents, these books will give the reader a comprehensive overview of the many different aspects of chemical warfare agent toxicology. The texts will appeal to toxicologists, biochemists and weapons specialists working in industry and academia, and anyone with an interest in chemical warfare toxicology or exposure.

Antimutagenesis and Anticarcinogenesis Mechanisms III (Paperback, Softcover reprint of the original 1st ed. 1993): Giorgio... Antimutagenesis and Anticarcinogenesis Mechanisms III (Paperback, Softcover reprint of the original 1st ed. 1993)
Giorgio Bronzetti, Hikoya Hayatsu, Silvio De Flora, Michael D Waters, Delbert M. Shankel
R1,467 Discovery Miles 14 670 Out of stock

Lifestyle, in any part of the world, is associated with the occurrence of major chronic diseases, including coronary heart disease, hypertension, and stroke; many distinct types of cancer; and adult onset diabetes (11,22,70,75). One important element of lifestyle is tobacco use, which appreciably increases the risk of a number of chronic diseases (21). Other lifestyle factors relate to nutritional traditions, alcohol use, and exercise (11,30,58,60,70,71). The underlying evidence is, in part, based on the evidence of specific diseases in relation to dietary habits in a given geographic region, as well as changes in such disease occurrences in migrant populations from a low risk to a high risk area, and vice versa (25,42). Populations that customarily consume fruits and vegetables and also whole grain cereal products generally have a lower risk of cardiovascular diseases and specific types of cancer than populations with a lower intake of such foods, everything else being equal (63). In the last few years, research has provided mechanistic explanations as to the reasons for the protective effects of specific foods. This paper will emphasize the mechanisms whereby cancer risks are reduced by dietary modification.

Genetic Toxicology of Complex Mixtures (Paperback, Softcover reprint of the original 1st ed. 1990): Michael D Waters, F.... Genetic Toxicology of Complex Mixtures (Paperback, Softcover reprint of the original 1st ed. 1990)
Michael D Waters, F. Bernhard Daniel, Joellen Lewtas, Martha M. Moore, Stephen Nesnow
R1,985 Discovery Miles 19 850 Out of stock

Contained in this volume are the proceedings of the international conference on the "Genetic Toxicology of Complex Mixtures," held from July 4-7, 1989, in Washington, DC. This meeting was a satellite of the "Fifth International Conference on Environmental Mutagens" and the seventh in a biennial series of conferences on "Short-term Bioassays in the Analysis of Complex Environmental Mixtures. " Our central objective in calling together key researchers from around the world was to extend our knowledge of the application of the methods of genetic toxicology and analytical chemistry in the evaluation of chemical mixtures as they exist in the environment. This conference emphasized the study of genotoxicants in air and water, and the assessment of human exposure and cancer risk. The latest strategies and methodologies for biomonitoring of genotoxicants (including transformation products) were described in the context of the ambient environment. Source character ization and source apportionment were discussed as an aid to understand ing the origin and relative contribution of various kinds of complex mix tures to the ambient environment. Similarly, investigations of genotoxi cants found in the indoor environment (sidestream cigarette smoke) and in drinking water (chlorohydroxyfuranones) were given special attention in terms of their potential health impacts. New molecular techniques were described to enable more precise quantitation of internal dose and dose to-target tissues. The emphasis of presentations on exposures/effects assessment was on integrated quantitative evaluation of human exposure and potential health effects.

Short-Term Bioassays in the Analysis of Complex Environmental Mixtures III (Paperback, Softcover reprint of the original 1st... Short-Term Bioassays in the Analysis of Complex Environmental Mixtures III (Paperback, Softcover reprint of the original 1st ed. 1983)
Michael D Waters
R1,468 Discovery Miles 14 680 Out of stock

In the four years since the 1978 Symposium on the Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures the use of short-term bioassays to evaluate potential health hazards of complex environmental mixtures has substantially increased. Increased research activity has been particularly noticeable in mobile source emissions, where initial observations on the mutagenic activity of diesel particulate extracts reported at the 1978 symposium stimulated the development of major research programs in government and industry. In the absence of appropriate reference materials, the U.S. Environmental Protection Agency initiated comparative genotoxicity studies to determine the relative mutagenic and carcinogenic activity and, ultimately, the potential human health risk due to exposure to various complex emission products. Among the materials investigated were those of known health risk, such as coke oven and roofing tar emissions and cigarette smoke condensates, and those of unknown hazard, such as exhaust from diesel-and gasoline-powered vehicles. Studies on diesel emission products proved useful in short- term bioassay development, as the diesel exhaust extracts were genetically active with low cellular toxicity and could be obtained in relatively large quantities. Availability of such samples aided chemical characterization, and it was eventually determined that the nitro-polynuclear aromatic hydrocarbons were among the mutagenic components of diesel exhaust particulate.

Antimutagenesis and Anticarcinogenesis Mechanisms II (Hardcover, 1990 ed.): Yukioki Kuroda, Delbert M. Shankel, Michael D Waters Antimutagenesis and Anticarcinogenesis Mechanisms II (Hardcover, 1990 ed.)
Yukioki Kuroda, Delbert M. Shankel, Michael D Waters
R1,895 Discovery Miles 18 950 Out of stock

The papers are arranged in eight sections, addressing: antimutagens in food; antimutagens and anticarcinogens in environmental toxicology; free radicals; antitumor initiators; antitumor promoters; aspects of mammalian and human genetics; molecular aspects of mutagenesis and antimutageneis; and oncog

Translational Toxicology - Defining a New Therapeutic Discipline (Hardcover, 1st ed. 2016): Claude L. Hughes, Michael D Waters Translational Toxicology - Defining a New Therapeutic Discipline (Hardcover, 1st ed. 2016)
Claude L. Hughes, Michael D Waters
R4,069 Discovery Miles 40 690 Out of stock

Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology-a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice. Translational Toxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.

Translational Toxicology - Defining a New Therapeutic Discipline (Paperback, Softcover reprint of the original 1st ed. 2016):... Translational Toxicology - Defining a New Therapeutic Discipline (Paperback, Softcover reprint of the original 1st ed. 2016)
Claude L. Hughes, Michael D Waters
R3,985 Discovery Miles 39 850 Out of stock

Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology-a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice. Translational Toxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.

Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures (Hardcover, 1979 ed.):... Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures (Hardcover, 1979 ed.)
Michael D Waters
R1,907 Discovery Miles 19 070 Out of stock

vi Williamsburg, Virginia, February 21-23, 1978. This symposium was sponsored by the U. S. Environmental Protection Agency, Office of Energy Minerals and Industry, Washington, DC, and Office of Health and Ecological Effects, Health Effects Re- search Laboratory, Biochemistry Branch, Research Triangle Park, NC. The symposium consisted of 24 formal presentations that amplify the three major topics discussed during the symposium: an overview of short-term bioassay systems; current methodology involving the collection and chemical analysis of environmental samples; and current research in- volving the use of short-term bioassays in the fractionation and analysis of complex environmental mixtures. The purpose of this symposium was to present the state-of-the-art tech- niques in bioassay and chemical analysis as applied to com- plex mixtures and to foster continued advancement of this important area. Complex mixtures discussed include ambient air and water, waste water, drinking water, shale oil, syn- thetic fuels, automobile exhaust, diesel particulate, coal fly ash, cigarette smoke condensates, and food products. It is our hope that this volume will serve as a refer- ence to catalyze and encourage further research in this field. Michael D. Waters, Ph. D. Stephen Nesnow, Ph. D. vii Acknowledgment We would like to thank Gerald Rausa, Office of Energy Minerals and Industry, for his advice, encouragement, and support of this program. We would also like to express our appreciation to Wendy A. Martin, Peter A. Murphy, and David F. Wright of Kappa Systems, Inc.

Translational Toxicology and Therapeutics - Windows of Developmental Susceptibility in Reproduction and Cancer (Hardcover):... Translational Toxicology and Therapeutics - Windows of Developmental Susceptibility in Reproduction and Cancer (Hardcover)
Michael D Waters, Claude L. Hughes
R5,181 R3,631 Discovery Miles 36 310 Save R1,550 (30%) Ships in 7 - 13 working days

Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. Provides information on lifestyle choices that can reduce cancer risk Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants Helps readers develop new animal models and tests to assess toxic impacts of mutation and cancer on human health Explains specific cellular and molecular targets of known toxicants operating through genetic and epigenetic mechanisms

Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures (Paperback, Softcover... Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures (Paperback, Softcover reprint of the original 1st ed. 1978)
Michael D Waters
R1,472 Discovery Miles 14 720 Out of stock

vi Williamsburg, Virginia, February 21-23, 1978. This symposium was sponsored by the U. S. Environmental Protection Agency, Office of Energy Minerals and Industry, Washington, DC, and Office of Health and Ecological Effects, Health Effects Re- search Laboratory, Biochemistry Branch, Research Triangle Park, NC. The symposium consisted of 24 formal presentations that amplify the three major topics discussed during the symposium: an overview of short-term bioassay systems; current methodology involving the collection and chemical analysis of environmental samples; and current research in- volving the use of short-term bioassays in the fractionation and analysis of complex environmental mixtures. The purpose of this symposium was to present the state-of-the-art tech- niques in bioassay and chemical analysis as applied to com- plex mixtures and to foster continued advancement of this important area. Complex mixtures discussed include ambient air and water, waste water, drinking water, shale oil, syn- thetic fuels, automobile exhaust, diesel particulate, coal fly ash, cigarette smoke condensates, and food products. It is our hope that this volume will serve as a refer- ence to catalyze and encourage further research in this field. Michael D. Waters, Ph. D. Stephen Nesnow, Ph. D. vii Acknowledgment We would like to thank Gerald Rausa, Office of Energy Minerals and Industry, for his advice, encouragement, and support of this program. We would also like to express our appreciation to Wendy A. Martin, Peter A. Murphy, and David F. Wright of Kappa Systems, Inc.

Genetic Toxicology of Complex Mixtures - Symposium Proceedings (Hardcover, New): Michael D Waters, Etc Genetic Toxicology of Complex Mixtures - Symposium Proceedings (Hardcover, New)
Michael D Waters, Etc
R1,878 Discovery Miles 18 780 Out of stock

Contained in this volume are the proceedings of the international conference on the "Genetic Toxicology of Complex Mixtures," held from July 4-7, 1989, in Washington, DC. This meeting was a satellite of the "Fifth International Conference on Environmental Mutagens" and the seventh in a biennial series of conferences on "Short-term Bioassays in the Analysis of Complex Environmental Mixtures. " Our central objective in calling together key researchers from around the world was to extend our knowledge of the application of the methods of genetic toxicology and analytical chemistry in the evaluation of chemical mixtures as they exist in the environment. This conference emphasized the study of genotoxicants in air and water, and the assessment of human exposure and cancer risk. The latest strategies and methodologies for biomonitoring of genotoxicants (including transformation products) were described in the context of the ambient environment. Source character ization and source apportionment were discussed as an aid to understand ing the origin and relative contribution of various kinds of complex mix tures to the ambient environment. Similarly, investigations of genotoxi cants found in the indoor environment (sidestream cigarette smoke) and in drinking water (chlorohydroxyfuranones) were given special attention in terms of their potential health impacts. New molecular techniques were described to enable more precise quantitation of internal dose and dose to-target tissues. The emphasis of presentations on exposures/effects assessment was on integrated quantitative evaluation of human exposure and potential health effects."

Antimutagenesis and Anticarcinogenesis Mechanisms II (Paperback, Softcover reprint of the original 1st ed. 1990): Yukioki... Antimutagenesis and Anticarcinogenesis Mechanisms II (Paperback, Softcover reprint of the original 1st ed. 1990)
Yukioki Kuroda, Delbert M. Shankel, Michael D Waters
R1,460 Discovery Miles 14 600 Out of stock
Short-Term Bioassays in the Analysis of Complex Environmental Mixtures III (Hardcover, 1983 ed.): Michael D Waters Short-Term Bioassays in the Analysis of Complex Environmental Mixtures III (Hardcover, 1983 ed.)
Michael D Waters
R2,479 Discovery Miles 24 790 Out of stock

In the four years since the 1978 Symposium on the Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures the use of short-term bioassays to evaluate potential health hazards of complex environmental mixtures has substantially increased. Increased research activity has been particularly noticeable in mobile source emissions, where initial observations on the mutagenic activity of diesel particulate extracts reported at the 1978 symposium stimulated the development of major research programs in government and industry. In the absence of appropriate reference materials, the U.S. Environmental Protection Agency initiated comparative genotoxicity studies to determine the relative mutagenic and carcinogenic activity and, ultimately, the potential human health risk due to exposure to various complex emission products. Among the materials investigated were those of known health risk, such as coke oven and roofing tar emissions and cigarette smoke condensates, and those of unknown hazard, such as exhaust from diesel-and gasoline-powered vehicles. Studies on diesel emission products proved useful in short- term bioassay development, as the diesel exhaust extracts were genetically active with low cellular toxicity and could be obtained in relatively large quantities. Availability of such samples aided chemical characterization, and it was eventually determined that the nitro-polynuclear aromatic hydrocarbons were among the mutagenic components of diesel exhaust particulate.

Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II (Paperback, Softcover reprint of the original 1st ed.... Short-Term Bioassays in the Analysis of Complex Environmental Mixtures II (Paperback, Softcover reprint of the original 1st ed. 1980)
Michael D Waters, Stephen Nesnow, Joellen L Huisingh, Shahbeg S. Sandhu, Larry Claxton
R1,472 Discovery Miles 14 720 Out of stock

More than one hundred short-term bioassays are now available for detecting the toxicity, mutagenicity, and potential carcinogenicity of chemicals. These bioassays were developed and validated with individual compounds, and their principal application was perceived to be in evaluating the health hazard of such materials. However, man is rarely exposed to single chemicals; his exposure to hazardous chemicals is more commonly a multifactorial phenomenon. Although chemical analysis can be used to detect known hazardous compounds, it would be a staggering and expensive task to analyze large numbers of samples for all known or suspected hazardous constituents. Furthermore, the biological activity of a complex mixture cannot be reliably predicted from knowledge of its components. On the other hand, bioassays alone cannot tell us which components of complex mixtures are responsible for the biological activity detected. Thus, cost effectiveness and technical feasibility dictate stepwise and perhaps iterative application -of both chemical and biological methods in evaluating the health effects of complex environmental mixtures. Through the coupling of reliable biological detection systems with methods of chemical fractionation and analysis, it is frequently possible to isolate the individual chemical species that show biological activity. Initially, complex mixtures may be separated and bioassayed in carefully defined chemical fractions. The results of such short-term screening bioassays then may be used td guide the course of further fractionation and to determine the need for more stringent and comprehensive biological testing.

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