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Liquid markets generate hundreds or thousands of ticks (the minimum
change in price a security can have, either up or down) every
business day. Data vendors such as Reuters transmit more than
275,000 prices per day for foreign exchange spot rates alone. Thus,
high-frequency data can be a fundamental object of study, as
traders make decisions by observing high-frequency or tick-by-tick
data. Yet most studies published in financial literature deal with
low frequency, regularly spaced data. For a variety of reasons,
high-frequency data are becoming a way for understanding market
microstructure. This book discusses the best mathematical models
and tools for dealing with such vast amounts of data.
H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind - assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the 'bible' of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.
This book reports on the first substantial UK study of parenting, disability and mental health. It examines the views of parents and children in 75 families. Covering a broad spectrum of issues facing disabled parents and their families, Parenting and disability: provides a comprehensive review of relevant policy issues; explores the barriers to full participation in parenting that disabled parents face; examines the complex ways in which broader social divisions, including gender and socioeconomic status, interact with disability; advocates measures to support disabled parents and their families by promoting and supporting relationships within the family. The book is aimed at a wide audience, including students and academics in social policy, social work, disability studies, sociology, education, and nursing, people working in the voluntary sector, disabled activists and their supporters, as well as policy makers and practitioners in a range of statutory agencies.
Apollo Journal is a true history of the lunar landing in July 1969 that culminated 2500 years of dreaming, conflict, the struggle of ideas and finally the physical reality confronting Apollo astronauts. The genesis of space travel traces back at least to the classical Greek world of 500 B.C. when astronomers speculated about the universe's structure.Cosmology. Disputes about the structure of the universe (earth-centered or sun- centered) covered a time period of 500 B.C. to the 17th century. Violence and cruelty characterized much of this dispute. Greeks killed Greeks; Christianity adopted the earth-centered geocentric theory as gospel; which led to the Tyranny of the Church and the infamous trial of Galileo. In the interim, Rome conquered Greece. Islamic forces invaded Europe, Europeans launched the crusades and the Renaissance occurred. British astronomer-scientist Sir Isaac Newton laid the issue to rest with his Universal Laws of Motion. Rockets. A reliable means of propulsion capable of lifting a space vehicle out of earth's atmosphere had to be developed. Rockets, whose first use is credited to the Chinese in the 13th century, were used for celebrations and waging war, but were unreliable and unsafe. However, governments and private groups experimented with rockets, striving to improve their safety and guidance systems until the launch of Sputnik in 1957 established the rocket as the propulsion system of choice for space exploration.Space Race.The space race between United States and the Soviet Union commenced when President Kennedy proposed to Congress and the Nation the Apollo lunar landing project in 1961. The Nation's wars, budget battles, Watergate and economic conditions haveall impacted manned space programs. Mismanagement has characterized much of manned space programs, which coupled with human error, resulted in years of schedule slips, horrendous waste of taxpayers' money, four major accidents and the death of seventeen astronauts. In spite of this, the Nation's space programs represent unique accomplishments in world history.Third Millennium. Manned space programs are now in limbo pending the findings of the Columbia Shuttle review panel. NASA plans to resume Shuttle flights perhaps in the latter part of the year (2005), but the future of manned space operation is uncertain.
It costs more to place a child in the care of a local authority than it does to send a child to a top boarding school, and there are substantial variations in costs both between and within authorities. This book gets to the bottom of the costs of care and provides an insight into how these variations in cost relate to differences in children's needs, and most importantly, whether higher costs reflect better services and better outcomes for children. Costs and Consequences for Children Placed Away from Home draws from new original research, and considers the implications for best practice and future policy. It also features information about a newly pioneered resource: a fully workable decision analysis model designed for use in local authorities which uses historical data for each child to calculate the probable cost consequences of difference placement choices. This book sheds light on how to calculate the financial and social costs of care, and will be invaluable to both social work managers and policy makers working in children's services.
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