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Matrix Metalloproteinase Inhibitors - Specificity of Binding and Structure-Activity Relationships (Paperback, 2012 ed.): Satya... Matrix Metalloproteinase Inhibitors - Specificity of Binding and Structure-Activity Relationships (Paperback, 2012 ed.)
Satya Prakash Gupta
R3,086 R2,747 Discovery Miles 27 470 Save R339 (11%) Shipped within 7 - 12 working days

Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases. The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. The articles focus specifically on structure-activity relationships of all classes of compounds and on their modes of action and specificity of binding with the receptors based on experimental and theoretical studies. These studies constitute a valuable asset for all those involved in drug development.

Studies on Hepatitis Viruses - Life Cycle, Structure, Functions, and Inhibition (Paperback): Satya Prakash Gupta Studies on Hepatitis Viruses - Life Cycle, Structure, Functions, and Inhibition (Paperback)
Satya Prakash Gupta
R2,333 Discovery Miles 23 330 Shipped within 7 - 11 working days

Studies on Hepatitis Viruses: Life Cycle, Structure, Functions, and Inhibition presents the latest on this systemic infection that predominantly affects the liver with inflammation that can be acute or chronic. Hepatitis viruses have been the subject of intense study in the last twenty years, with a wealth of information related to their lifecycle, structure, functions and inhibition being presented. This book compiles the most important developments and research, giving users a very useful guide on this evolving area of virology and medicinal chemistry.

Matrix Metalloproteinase Inhibitors - Specificity of Binding and Structure-Activity Relationships (Hardcover, 2012 ed.): Satya... Matrix Metalloproteinase Inhibitors - Specificity of Binding and Structure-Activity Relationships (Hardcover, 2012 ed.)
Satya Prakash Gupta
R4,406 R3,689 Discovery Miles 36 890 Save R717 (16%) Shipped within 7 - 12 working days

Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases. The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. The articles focus specifically on structure-activity relationships of all classes of compounds and on their modes of action and specificity of binding with the receptors based on experimental and theoretical studies. These studies constitute a valuable asset for all those involved in drug development.

Cancer-Causing Viruses and Their Inhibitors (Hardcover): Satya Prakash Gupta Cancer-Causing Viruses and Their Inhibitors (Hardcover)
Satya Prakash Gupta
R2,564 Discovery Miles 25 640 Shipped within 7 - 12 working days

Cancer-causing viruses, also called oncoviruses, play a key role in the development of certain cancers. They contribute to genetic changes that disrupt the cell cycle machinery, interfering with functions such as cell growth. Cancer-Causing Viruses and Their Inhibitors presents a plethora of research from internationally reputed contributors who discuss different types of oncoviruses, their mechanisms of invasion and growth, and their life cycles. The book begins with an overview of the oncoviruses discovered to date and includes a brief description of their structures, genotypes, replication, and mechanisms of infection leading to cancers. It then explores several of these viruses in detail, including: Human T-cell leukemia virus type 1 (HTLV-1) Hepatitis C virus (HCV) Epstein-Barr virus (EBV) Human papilloma virus (HPV) Human herpes virus 8 (HHV-8)/Kaposi's sarcoma-associated herpes virus (KSHV) Human immunodeficiency virus (HIV/AIDS) Oncolytic viruses This book is an essential reference for those working in virology, oncology, and biotechnology. The discoveries presented will enable researchers and clinicians to optimize both historical and current approaches to anti-viral therapies.

Cancer-Causing Viruses and Their Inhibitors (Paperback): Satya Prakash Gupta Cancer-Causing Viruses and Their Inhibitors (Paperback)
Satya Prakash Gupta
R1,195 Discovery Miles 11 950 Special order

Cancer-causing viruses, also called oncoviruses, play a key role in the development of certain cancers. They contribute to genetic changes that disrupt the cell cycle machinery, interfering with functions such as cell growth. Cancer-Causing Viruses and Their Inhibitors presents a plethora of research from internationally reputed contributors who discuss different types of oncoviruses, their mechanisms of invasion and growth, and their life cycles. The book begins with an overview of the oncoviruses discovered to date and includes a brief description of their structures, genotypes, replication, and mechanisms of infection leading to cancers. It then explores several of these viruses in detail, including: Human T-cell leukemia virus type 1 (HTLV-1) Hepatitis C virus (HCV) Epstein-Barr virus (EBV) Human papilloma virus (HPV) Human herpes virus 8 (HHV-8)/Kaposi's sarcoma-associated herpes virus (KSHV) Human immunodeficiency virus (HIV/AIDS) Oncolytic viruses This book is an essential reference for those working in virology, oncology, and biotechnology. The discoveries presented will enable researchers and clinicians to optimize both historical and current approaches to anti-viral therapies.

Ion Channels and Their Inhibitors (Paperback, 2011 ed.): Satya Prakash Gupta Ion Channels and Their Inhibitors (Paperback, 2011 ed.)
Satya Prakash Gupta
R2,218 R2,107 Discovery Miles 21 070 Save R111 (5%) Special order

Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with target based ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover important recent advances in the studies of the structure and functions of ion channels and their inhibitors, such as sodium ion, potassium ion, chloride ion, calcium ion channel inhibitors. The book may be of great use to the students and scientists working in the area of molecular biology, biochemistry, physiology, neurobiology, and medicinal chemistry.

Viral Polymerases - Structures, Functions and Roles as Antiviral Drug Targets (Paperback): Satya Prakash Gupta Viral Polymerases - Structures, Functions and Roles as Antiviral Drug Targets (Paperback)
Satya Prakash Gupta
R2,559 R2,427 Discovery Miles 24 270 Save R132 (5%) Special order

Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets presents in-depth study information on the structure and functions of polymerases and their roles in the lifecycle of viruses, and as drug targets. Viral polymerases constitute a vital component in the lifecycle of many viruses, such as human immunodeficiency virus (HIV), hepatitis viruses, influenza virus, and several others. They are essentially required for the replication of viruses. Thus, the polymerases that can be found in viruses (called viral polymerases) represent favorable targets for the design and development of antiviral drugs.

Viral Proteases and Their Inhibitors (Paperback): Satya Prakash Gupta Viral Proteases and Their Inhibitors (Paperback)
Satya Prakash Gupta
R2,020 Discovery Miles 20 200 Special order

Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents.

QSAR and Molecular Modeling (Hardcover, 1st ed. 2101): Satya Prakash Gupta QSAR and Molecular Modeling (Hardcover, 1st ed. 2101)
Satya Prakash Gupta
R2,693 R2,552 Discovery Miles 25 520 Save R141 (5%) Special order

"QSAR and Molecular Modeling" includes all the fundamentals of these approaches developed so far. Starting with the fundamentals of drug-receptor interactions, it covers various statistical approaches, different 2D QSAR methodologies, theories and values of useful variables governing biological activities, and popular 3D molecular modeling approaches. Graduate and postgraduate students of biological, pharmaceutical and chemical sciences along with those working in drug industries and research institutes will find this book of immense use.

Ion Channels and Their Inhibitors (Hardcover, 2011 ed.): Satya Prakash Gupta Ion Channels and Their Inhibitors (Hardcover, 2011 ed.)
Satya Prakash Gupta
R2,445 R2,320 Discovery Miles 23 200 Save R125 (5%) Special order

Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with targets based on ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover important recent advances in the studies of the structure and functions of ion channels and their inhibitors, such as sodium Ion, potassium Ion, chloride Ion, calcium Ion channel inhibitors. The book may be of great use to the students and scientists working in the area of molecular biology, biochemistry, physiology, and neurobiology, and medicinal chemistry.

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