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Showing 1 - 25 of 29 matches in All departments

Cat Chaser (Paperback, New Ed): Elmore Leonard Cat Chaser (Paperback, New Ed)
Elmore Leonard; Designed by Tim Marrs
R259 R228 Discovery Miles 2 280 Save R31 (12%) Ships in 10 - 15 working days

A lean and mean thriller about one man and the Mob from 'the crime laureate' INDEPENDENT. The last time Florida motel owner George Moran was in the Dominican Republic he was in a uniform and people were shooting at him. Years later he's back looking for a girl he lost - and finding one he'd be better off without. Mary de Boya may be beautiful, but she's also the wife of a former death squad general in exile with mob connections. So much for the trip down memory lane - now Moran finds himself in a cat's cradle of drug deals, swindles, vengeance and murder. 'Dialogue like broken glass, sharp and glittering, and a raft of low-lifes individualised in primary colours like hard-edged pop art' Independent

The Cellular Response to the Genotoxic Insult - The Question of Threshold for Genotoxic Carcinogens (Hardcover): Helmut Greim,... The Cellular Response to the Genotoxic Insult - The Question of Threshold for Genotoxic Carcinogens (Hardcover)
Helmut Greim, Richard J. Albertini; Series edited by Tim Marrs, Diana Anderson, Mike Waters; Contributions by …
R4,961 Discovery Miles 49 610 Ships in 10 - 15 working days

Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer. Typically, a series of mutation events are needed before malignancy occurs so a single, small exposure may not result in disease. Also, cells have an armoury of defence mechanisms which, to a degree, counter the effects of mutagens. Distinguishing the point at which exposure to a carcinogen increases mutation rates beyond the background level is challenging. In fact, there is now general agreement that, for genotoxic carcinogens, no specific threshold can be identified. However, NOAELs (No Observed Adverse Effect Levels) may be used in the process of establishing a dose-response relationship. These denote the level of exposure at which there is no significant increase in adverse effects in the exposed population when compared to an appropriate control. Such a scientifically defendable threshold allows us to propose health based exposure limits for genotoxic carcinogens. This book describes the various cellular defence mechanisms individually and explains how they are regulated. The processes covered include metabolic inactivation, epigenetic regulation, scavenging mechanisms, DNA-repair and apoptosis. It also considers dose-dependent threshold mechanisms of carcinogenesis and the rate limiting parameters. Aimed at graduate level and above, the book discusses the consequences of genotoxic evaluation and urges readers to question the idea that even low exposures present a cancer risk.

Computational Systems Pharmacology and Toxicology (Hardcover): Rudy J. Richardson Computational Systems Pharmacology and Toxicology (Hardcover)
Rudy J. Richardson; Edited by (editors-in-chief) Diana Anderson; Series edited by Tim Marrs; Translated by Michael D Waters; Contributions by Dale E Johnson, …
R4,644 Discovery Miles 46 440 Ships in 10 - 15 working days

This book will be important for scientists involved in environmental research particularly in filling data gaps for risk assessment. It also will highlight key methods used in studying biological targets both from a toxicity standpoint and pharmacological activity. It provides a systems pharmacology/toxicology approach to computational toxicology, linking chemical exposures to genes, diseases, and complex biological/disease pathways. It also provides the discussion of new approaches to study chemical such as biological target elucidation and move this into computational models. Overall the book expands the computational focus of chemicals and biological interactions into the field of herbal and traditional medicines. It is noteworthy that the book reaches beyond pharmaceutical toxicology. The book will be a useful academic course book for both graduate and undergraduates studying pharmacology. It applies to areas such as Computational Toxicology; Systems biology; chemical-protein interactions; Interactions between Traditional Chinese Medicines/herbal medicines and Western therapeutics. Cross-promote this book with Big Data in Predictive Toxicology.

Aerobiology - The Toxicology of Airborne Pathogens and Toxins (Hardcover): Harry Salem, Sidney A. Katz Aerobiology - The Toxicology of Airborne Pathogens and Toxins (Hardcover)
Harry Salem, Sidney A. Katz; Series edited by Tim Marrs; Edited by (editors-in-chief) Diana Anderson; Contributions by Terry J. Henderson, …
R5,234 Discovery Miles 52 340 Ships in 10 - 15 working days

Aerobiology is the study of airborne organic particulates in the environment, such as bacteria or fungal spores. These can be either naturally occurring or artificially introduced into the air. Some of the toxicological, pharmacological, and physiological effects of bioaerosols include infections, allergies, and cancer. Research efforts in aerobiology range from remediating household mould to combating bioterrorism. This book focusses on the toxicological aspects of aerobiology, considering the adverse health effects associated with the inhalation of specific bioaerosols, such as anthrax and ricin. Additionally, chapters cover techniques for generating, sampling and characterizing airborne biological materials as well as methods for establishing standards of exposure. Moreover, mitigation of exposure and protection against exposure are described. Bringing together the contemporary status of information in the area, this book will be a valuable reference book for pulmonary specialists, general practitioners of medicine, public health and public safety officers, first responders, military personnel, and students studying toxicology and related disciplines.

Aging and Vulnerability to Environmental Chemicals - Age-related Disorders and their Origins in Environmental Exposures... Aging and Vulnerability to Environmental Chemicals - Age-related Disorders and their Origins in Environmental Exposures (Hardcover)
Bernard Weiss; Series edited by Diana Anderson, Tim Marrs, Mike Waters, Martin F. Wilks; Contributions by …
R4,542 Discovery Miles 45 420 Ships in 10 - 15 working days

The world's aging populations, with age-related disorders affecting every organ system, are generating medical care costs rising at an unsustainable rate. Although such disorders are expected, we are now beginning to ask whether exposures to toxic environmental chemicals hasten or account for their onset. This book provides a detailed review of current knowledge about the possible associations between a variety of chemical contaminants and adverse effects later in life. It will serve as a guide to policy decisions about protecting us from chemical exposures that distort the aging process. It provides a guide to current understanding of how our contaminated environment may be influencing the aging process and contains examples of approaches that will help us undertake further research on this topic. It will help alert policy makers to the implications of chemical pollution for aging populations and will help formulate initiatives for environmental protection. The book provides a comprehensive view of how environmental exposures may alter the health of our aging population. For readers engaged in environmental research, or aging research, it will highlight a number of questions that need more attention For other readers, they will learn something about the kind of exposures they should avoid or that they should prompt policy makers to reduce or eliminate.

Mammalian Toxicology of Insecticides (Hardcover): Tim Marrs Mammalian Toxicology of Insecticides (Hardcover)
Tim Marrs; Series edited by Diana Anderson, Mike Waters, Tim Marrs; Contributions by Janice E. Chambers, …
R4,259 Discovery Miles 42 590 Ships in 10 - 15 working days

Insects are more similar in structure and physiology to mammals than plants or fungi. Consequently, insecticides are often of greater toxicity to mammals than herbicides. This is particularly the case with neurotoxins. However, some insecticides are targeted at structures or hormonal systems specific to insects (insect growth regulators/chitin synthesis inhibitors) so are less harmful but can still be mildly haematotoxic. There are, therefore, issues specific to insecticides, which do not occur with other pesticides - hence the need for a book specifically on insecticide toxicology in mammals. The book starts with general issues relating to the mammalian toxicity of insecticides, including target/non-target specificity, nomenclature and metabolism of insecticides. It then goes on to discuss specific types of insecticides including: organochlorines; anticholinesterases; pyrethrum and synthetic pyrethroids; nicotine and the neonicotinoids; insect growth regulators/ecdysone agonists/chitin synthesis inhibitors; insecticides of natural origin; biological insecticides; and insecticides used in veterinary medicine.

Environmental Cardiology - Pollution and Heart Disease (Hardcover, Edition.): Aruni Bhatnagar Environmental Cardiology - Pollution and Heart Disease (Hardcover, Edition.)
Aruni Bhatnagar; Series edited by Diana Anderson, Mike Waters, Tim Marrs; Contributions by Jesus Araujo, …
R3,590 Discovery Miles 35 900 Ships in 10 - 15 working days

Although it is widely recognized that environmental factors such as smoking, diet, exercise, and socioeconomic status affect the risk of cardiovascular disease, recent work showing the effects of other environmental factors provides a more complete assessment of the situation. This view has emerged from three developments. Firstly, there has been a sudden explosion in the prevalence of diabetes and obesity which indicates a strong environmental component. Secondly, there is an accumulation of evidence suggesting that most cases of these diseases could be prevented by healthy lifestyle choices. Finally, studies have shown that exposure to environmental pollutants has a significant effect on heart disease risk. This book is the first to provide a comprehensive account of the effects of pollutants on heart disease and to integrate this area of research within the overall theme of environmental cardiology. The introductory chapter outlines the effects of different aspects of the environment on heart disease and provides a context for the discussion that follows. Subsequent chapters give an overview of the effects of particulate matter and discuss the epidemiological studies supporting the link. The book then goes on to cover the effects of pollution on different aspects of cardiovascular disease (hypertension, stroke, heart failure, ischemic heart disease and atherogenesis). Because of a close association between diabetes and heart disease, a discussion of the effects of particulate matter on diabetes is also included. Later chapters discuss the effects of individual pollutants such as vehicular emissions, metals and aldehydes. A review on manufactured nanoparticles is incorporated because these particles represent an important new threat to cardiovascular health. The understanding that emerges from this monograph suggests that we must be more alert to the effects of the environment and develop strategies that target, not only the diseased individual, but also the unhealthy, disease-causing environment. It is essential reading for cardiologists, epidemiologists, urban planners and pollution control specialists.

Rethinking TESOL in Diverse Global Settings - The Language and the Teacher in a Time of Change (Paperback): Tim Marr, Fiona... Rethinking TESOL in Diverse Global Settings - The Language and the Teacher in a Time of Change (Paperback)
Tim Marr, Fiona English
R663 Discovery Miles 6 630 Ships in 10 - 15 working days

What do TESOL teachers actually teach? What do they know about language, about English and the ways it is used in the world? How do they view themselves and their work, and how are they viewed by others? How is TESOL perceived as a profession and as a discipline? How can teachers make the most of the available resources? Can global English really deliver what it seems to promise? These are some of the questions explored in Rethinking TESOL in Diverse Global Settings, a book which examines what we mean when we talk about English language teaching and what we understand the job of an English language teacher to be. Covering diverse teaching environments, from China to Latin America and the Middle East, and from elementary school to university, the authors take a critical look at TESOL by focusing on the actual substance of the subject, language, and attitudes towards it. Through concrete examples from language classrooms, in the form of vignettes and accounts from native speaker and non-native speaker teachers alike, they explore the experiences of teachers worldwide in relation to issues of identity and professionalism, nativeness and non-nativeness, and the pressures of dealing with the expectations with which English has become invested. While recognising the often precarious academic and institutional status of TESOL teachers, the book pulls no punches in challenging those teachers as a whole to become more ambitious in their aims, positioning themselves not as mere skills providers, but language experts, specialists in their subject, members of a legitimate academic discipline. Only then, the authors argue, will TESOL teachers and their work be taken seriously and their expertise recognised.

Toxicological Effects of Veterinary Medicinal Products in Humans - Volume 2 (Hardcover): Kevin Woodward Toxicological Effects of Veterinary Medicinal Products in Humans - Volume 2 (Hardcover)
Kevin Woodward; Contributions by Peter Silley, Derek Renshaw; Series edited by Tim Marrs
R4,511 Discovery Miles 45 110 Ships in 10 - 15 working days

Toxicological Effects of Veterinary Medicinal Products in Humans is the first definitive guide to discuss the adverse effects of veterinary medicinal products in humans. The chapters focus on occupational safety and consumer issues and examine the circumstances under which exposure is likely to occur. To be in context, it reviews this against the background of adverse health effects from other sources in the veterinary and farming professions. The book examines adverse drug effects reported to regulatory agencies (mainly the FDAAEs Center for Veterinary Medicine) and then considers a series of individual drugs, including antibiotics, anaesthetics and organophosphorus compounds. The chapters also discuss the fundamental aspects of regulatory issues relating to safety assessment, and examine the manner in which user safety is assessed prior to authorisation/approval and what measures can be taken after authorisation/approval in the light of findings from pharmacovigilance activities. There is growing concern over the issue of antimicrobial resistance and the contribution made by veterinary medicinal products. This too is addressed along with the significance to human health and measures that can be taken to mitigate the effects (if any) of the use of antibiotics in animals e.g. prudent use measures. The book will be an essential resource for medical practitioners in hospitals and general practice, pharmaceutical industry scientists, analysts, regulators and risk managers.

Hormone-Disruptive Chemical Contaminants in Food (Hardcover): Ingemar Pongratz, Linda Bergander Hormone-Disruptive Chemical Contaminants in Food (Hardcover)
Ingemar Pongratz, Linda Bergander; Series edited by Diana Anderson, Tim Marrs, Mike Waters; Contributions by …
R3,889 Discovery Miles 38 890 Ships in 10 - 15 working days

Today, we are surrounded by a multitude of different chemicals that are essential components of our everyday life. As a consequence, there are various hazardous substances like dioxins, phthalates and flame-retardants circulating in the environment. These have an impact on ecosystems, wildlife and possibly human health. In recent years, the phenomenon called endocrine disruption has raised considerable concern. This book discusses the scientific basis of this issue using epidemiological and experimental in vitro and in vivo data about chemicals targeting the hormonal systems. It also provides an up-to-date review of international initiatives (including high-throughput screening, use of model organisms and in silico applications) aiming to screen, detect and functionally test these chemicals. The authors are highly experienced academics and acknowledged experts with both multidisciplinary and international expertise. The book provides an up-to-date, in-depth review of the current field of food safety research describing many of the "hot topics" currently debated. Recent media attention concerning, for example, dioxins in meat and bisphenol A in baby bottles has created a growing interest in food safety-related issues from both consumers and authorities. In addition, European legislation REACH, which requires industry to extensively test chemicals, has led to new initiatives within this area. This book presents a comprehensive overview of the recent international initiatives formed to meet the challenges of environmental pollutants in our food.

Biomarkers and Human Biomonitoring - Volume 2 (Hardcover): Lisbeth Knudsen, Domenico Franco Merlo Biomarkers and Human Biomonitoring - Volume 2 (Hardcover)
Lisbeth Knudsen, Domenico Franco Merlo; Series edited by Diana Anderson, Tim Marrs, Mike Waters; Contributions by …
R3,663 Discovery Miles 36 630 Ships in 10 - 15 working days

Human biomonitoring has developed from a research tool in occupational and environmental health to identify and quantify exposures to harmful substances in urine and blood. The analytical methods for detection of substances in biological media have considerably improved with smaller detection limits and more precise and specific measurements. Human biomonitoring is a valuable tool in exposure estimation of selected populations and currently used in surveillance programs all over the world. This two volume set provides an overview of current available biomarkers and human biomonitoring programs in environmental health, which is timely given the present debate on adverse health effects from environmental exposures. The books decribe both previous and ongoing studies as well as the newer biomarkers of exposure and effects. Volume one describes current human biomonitoring programs in Germany, Romania, France, Canada, India and Belgium, providing convincing evidence of a global decline in human exposures to lead and increasing concern from exposure to endocrine disruptors and the genotoxic compound. Biomarkers of specific exposures to a wide range of widely used everyday compounds such as phthalates, PFCs, bisphenol A, brominated flame retardants, PAHs, dioxins, mercury and arsenic are also discussed. Volume two decribes human biomonitoing of exposures to environmental tobacco smoke, mycotoxins, physiological stress, hormone activity, oxidative stress and ionizing radiation, as well as effect biomarkers of hemoglobin adducts, germ cells, micronuclei and individual susceptability. The books will be essential reading for toxicologists, environmental scientists and all those working in the safety and risk assessment of chemicals.

Biomarkers and Human Biomonitoring - Volume 1 (Hardcover): Lisbeth Knudsen, Domenico Franco Merlo Biomarkers and Human Biomonitoring - Volume 1 (Hardcover)
Lisbeth Knudsen, Domenico Franco Merlo; Series edited by Diana Anderson, Tim Marrs, Mike Waters; Contributions by …
R3,686 Discovery Miles 36 860 Ships in 10 - 15 working days

Human biomonitoring has developed from a research tool in occupational and environmental health to identify and quantify exposures to harmful substances in urine and blood. The analytical methods for detection of substances in biological media have considerably improved with smaller detection limits and more precise and specific measurements. Human biomonitoring is a valuable tool in exposure estimation of selected populations and currently used in surveillance programs all over the world. This two volume set provides an overview of current available biomarkers and human biomonitoring programs in environmental health, which is timely given the present debate on adverse health effects from environmental exposures. The books decribe both previous and ongoing studies as well as the newer biomarkers of exposure and effects. Volume one describes current human biomonitoring programs in Germany, Romania, France, Canada, India and Belgium, providing convincing evidence of a global decline in human exposures to lead and increasing concern from exposure to endocrine disruptors and the genotoxic compound. Biomarkers of specific exposures to a wide range of widely used everyday compounds such as phthalates, PFCs, bisphenol A, brominated flame retardants, PAHs, dioxins, mercury and arsenic are also discussed. Volume two decribes human biomonitoing of exposures to environmental tobacco smoke, mycotoxins, physiological stress, hormone activity, oxidative stress and ionizing radiation, as well as effect biomarkers of hemoglobin adducts, germ cells, micronuclei and individual susceptability. The books will be essential reading for toxicologists, environmental scientists and all those working in the safety and risk assessment of chemicals.

In Silico Toxicology - Principles and Applications (Hardcover, Edition.): Mark T. D. Cronin In Silico Toxicology - Principles and Applications (Hardcover, Edition.)
Mark T. D. Cronin; Series edited by Diana Anderson, Mike Waters, Tim Marrs; Edited by Judith Madden; Contributions by …
R4,418 Discovery Miles 44 180 Ships in 10 - 15 working days

In Silico methods to predict toxicity have become increasingly important recently, particularly in light of European legislation such as REACH and the Cosmetics Regulation. They are also being used extensively worldwide e.g. in the USA, Canada, Japan and Australia. In assessing the risk that a chemical may pose to human health or to the environment, focus is now being directed towards exploitation of in silico methods to replace in vivo or in vitro techniques. A prediction of potential toxicity requires several stages: 1) Collation and organisation of data available for the compound, or if this is not available, information for related compounds. 2) An assessment of the quality of the data. 3) Generation of additional information about the compound using computational techniques at various levels of complexity - calculation of physico-chemical properties, 2-D, 3-D / MO descriptors and specific receptor modelling / interaction. 4) Use of an appropriate strategy to predict toxicity - ie a statistically valid method which makes best use of all available information (mechanism of action, activity for related compounds, extrapolation across species and endpoints, likely exposure scenario amounts over time etc). 5) Consideration then needs to be given to how this information is used in the real world ie use of expert systems / tools as relevant to assessors (if sufficiently different to previous) - weight of evidence approaches. 6) Finally evidence should be presented from case studies within this area. No other publication brings together information on all of these areas in one book and this publication is unique in that it provides a logical progression through every one of these key stages and defines the use of computational approaches to predict the environmental toxicity and human health effects of organic chemicals. The volume is aimed at the developers and users of in silico toxicology and provides an analysis of all aspects required for in silico prediction of toxicology, including data collation, quality assessment and computational approaches. The contributions from recognised leaders in each of these areas include evidence of the use and applicability of approaches using real world case studies concerning both environmental and human health effects. The book provides a very useful single source reference for people working in this area including academics, professionals, under- and post-graduate students as well as Governmental Regulatory Scientists involved in chemical risk assessment and REACH.

The Comet Assay in Toxicology (Hardcover): Alok Dhawan, Diana Anderson The Comet Assay in Toxicology (Hardcover)
Alok Dhawan, Diana Anderson; Series edited by Mike D. Waters, Tim Marrs; Contributions by Alok Dhawan, …
R4,112 Discovery Miles 41 120 Ships in 10 - 15 working days

The vast number of chemicals existing or being added into the environment, have globally aroused great concern regarding their adverse effects in human population. Development and validation of sensitive and better test systems which can assess the adverse effects of chemicals at an early stage for intervention strategies to be implemented in time is currently in progress. This book documents the latest research and showcases the versatile, state-of-the-art technique - the Comet assay - in the field of modern toxicology. The assay is a simple, sensitive rapid and visual technique for the quantitative and qualitative assessment of DNA damage in single cells. The Comet Assay in Toxicology is the first book of its kind to be devoted exclusively to the Comet assay and its applications as an important tool in modern toxicology. This multi-author book will serve as both a reference and a guide to investigations in the biomedical, biochemical and pharmaceutical sciences. Written by investigators from the fields of genetic toxicology and human epidemiology, the authors have first-hand knowledge from their chosen sub-specialities and are active contributors to the peer-reviewed scientific literature. The book is divided into five major sections, reflecting the range of interest in the exploitation of this assay. The book's scope begins with an introduction section reviewing its genesis for those new to the technique and the current knowledge of the various fields in which it finds wide acceptance. This section sets the scene by explaining why the assay has become the most sensitive and sought after assay in modern toxicology. Next is a whole section that considers various procedures being followed to assess different types of DNA damage in various cell types and is contributed by experts in the respective fields. The third section puts together the specific applications of the assay in the diverse fields ranging from genetic toxicity testing to human monitoring, and environmental toxicology. The fourth section consists of the guidelines and recommendations for the conduct of the assay in in vitro and in vivo systems, based on the recommendations of the International Workgroups on genotoxicity test procedures. Finally, the book draws to a close with an assessment of the statistics used for the understanding of the data generated by the assay. This is a unique reference book as it provides the scientific community with the advances in Comet assay as well as its applications. It also incorporates a detailed section with instant and comprehensive information on the procedure of the assay and the latest protocols being used worldwide as well as statistical analyses to be followed. The book is aimed at students as well as scientists in the area of molecular epidemiology and genetic toxicology.

Male-mediated Developmental Toxicity (Hardcover): Diana Anderson, Martin H. Brinkworth Male-mediated Developmental Toxicity (Hardcover)
Diana Anderson, Martin H. Brinkworth; Series edited by Tim Marrs, Mike Waters; Contributions by R. John Aitken, …
R3,581 Discovery Miles 35 810 Ships in 10 - 15 working days

The issue of male germ line mutagenesis and the effects on developmental defects in the next generation has become increasingly high profile over recent years. Mutations are thought to be becoming more prevalent as a result of: exposure to chemicals in the environment, anti cancer regimes that use genotoxic agents and assisted conception techniques. In addition to the increasing frequency of mutations in the general population, attention is also being given to the effects of epigenetic events on future generations. Male-mediated Developmental Toxicity discusses these issues comprehensively and includes further analysis on the fundamental mechanisms of mutations. With both clinical and experimental sections, written by leading experts in the field, this book will appeal to both medical practitioners and researchers.

Toxicology, Survival and Health Hazards of Combustion Products (Hardcover): David A. Purser, Robert Maynard, James C. Wakefield Toxicology, Survival and Health Hazards of Combustion Products (Hardcover)
David A. Purser, Robert Maynard, James C. Wakefield; Series edited by Tim Marrs; Edited by (editors-in-chief) Diana Anderson; Contributions by …
R5,250 Discovery Miles 52 500 Ships in 10 - 15 working days

1. Highlights the effects on human health from products of combustion 2. Fires are a common source of exposure to smoke and a range of toxicologically active chemicals. 3. Toxicologists, health and safety officers, environmental scientists 4. Drug Discovery Series, Toxicology Research 5. This book provides comprehensive and detailed information on combustion processes, dispersion of combustion products, estimation of rate of production of products of combustion, dispersion of these products and their effects on health.

Ecotoxicology and Genotoxicology - Non-traditional Aquatic Models (Hardcover): Michael D Waters, Tim Marrs Ecotoxicology and Genotoxicology - Non-traditional Aquatic Models (Hardcover)
Michael D Waters, Tim Marrs; Edited by (editors-in-chief) Diana Anderson; Contributions by Miguel Santos, N Wagner
R5,238 Discovery Miles 52 380 Ships in 10 - 15 working days

The potential impact of anthropogenic pollutants such as agrochemicals on the environment is of global concern. Increasing use of certain compounds can result in contamination of food, water and atmospheric systems and in order to combat this pollution it is important to be able to accurately monitor the short and long term effects. This book describes the latest aquatic species models used as indicators of the toxic effects of environmental pollutants, including models that have not routinely been used. The book enables understanding of the effects of pollutants in non-target species, and therefore enables analysis of the effects on ecosystems. This book will be of interest to anyone interested in developing new biomarker species with high degrees of ecological relevance. It will serve as a useful resource for regulatory and research toxicologists, particularly those studying freshwater, marine water and sediment environments.

Ecotoxicology and Genotoxicology - Non-traditional Terrestrial Models (Hardcover): Michael D Waters, Tim Marrs Ecotoxicology and Genotoxicology - Non-traditional Terrestrial Models (Hardcover)
Michael D Waters, Tim Marrs; Edited by (editors-in-chief) Diana Anderson; Contributions by N Wagner
R5,313 R4,644 Discovery Miles 46 440 Save R669 (13%) Ships in 10 - 15 working days

The potential impact of anthropogenic pollutants such as agrochemicals on the environment is of global concern. Increasing use of certain compounds can result in contamination of food, water and atmospheric systems and in order to combat this pollution it is important to be able to accurately monitor the short and long term effects. This book describes the latest non-traditional terrestrial species models used as indicators of the toxic effects of environmental pollutants. The book enables understanding of the effects of pollutants in non-target species, and therefore enables analysis of the effects on ecosystems. This book will be of interest to anyone interested in developing new biomarker species with high degrees of ecological relevance. It will serve as a useful resource for regulatory and research toxicologists, particularly those interested in soil screening and the effects of pollutants on wildlife and insects and their use as biological indicators.

Chemical Warfare Toxicology - Complete Set (Hardcover): Horst Thiermann, John Jenner, Franz Worek Chemical Warfare Toxicology - Complete Set (Hardcover)
Horst Thiermann, John Jenner, Franz Worek; Series edited by Michael D Waters, Tim Marrs; Edited by (editors-in-chief) …
R8,724 Discovery Miles 87 240 Ships in 10 - 15 working days

Despite ongoing efforts to prohibit the production, storage and use of chemical warfare agents recent world events highlight the enduring threat to the population from these agents. Research efforts in various countries have resulted in novel insights into chemical warfare toxicology that has enabled the development of new approaches for the diagnosis and treatment of chemical warfare poisoning. This two-volume set provides an up-to-date treatise on the ongoing research into the toxicology of chemical warfare agents, the diagnosis and verification of exposure, and the pre- and post-exposure treatment of poisoning. Focussing on the most important representative nerve and blistering agents, whilst also covering other potential chemical warfare agents, these books will give the reader a comprehensive overview of the many different aspects of chemical warfare agent toxicology. The texts will appeal to toxicologists, biochemists and weapons specialists working in industry and academia, and anyone with an interest in chemical warfare toxicology or exposure.

Advances in Dermatological Sciences (Hardcover): Robert Chilcott, K.R. Brain Advances in Dermatological Sciences (Hardcover)
Robert Chilcott, K.R. Brain; Series edited by Diana Anderson, Tim Marrs, Mike Waters, …
R5,115 Discovery Miles 51 150 Ships in 10 - 15 working days

Advances in Dermatological Sciences collates major scientific research achievements over the last two years in a diverse range of dermatological research fields. Examples of key topics covered include experimental models, toxicology, regulatory, exposure assessment, therapeutics, cosmetics and decontamination. A unique feature of the book is the introductory chapter to each section that is written by an internationally-recognised expert summarising work to date, and explaining how new research contributes to our overall understanding of the skin and where the next major developments are likely to be focussed in the future. Each section contains several experimental research chapters that present contemporary research on 'hot topics' or major advances relevant to the dermatological sciences. The book incorporates a broad range of specialist topics rather than focussing on one single aspect so as to appeal to a broader audience. Thus, the proposed book will distil cutting-edge advances across all of the dermatological sciences into one major work and so provide a one-stop portal for accessing the current state of knowledge that will communicate both a readily accessible overview (in the form of introductory chapters) and also detailed, expert contributions. The text will be essential reading for interdisciplinary scientists working in dermal pharmacology, dermatological and dermatotoxicological sciences.

Chemical Toxicity Prediction - Category Formation and Read-Across (Hardcover): Mark T. D. Cronin, Judith Madden, Steven Enoch,... Chemical Toxicity Prediction - Category Formation and Read-Across (Hardcover)
Mark T. D. Cronin, Judith Madden, Steven Enoch, David Roberts; Series edited by Diana Anderson, …
R3,371 Discovery Miles 33 710 Ships in 10 - 15 working days

The aim of this book is to provide the scientific background to using the formation of chemical categories, or groups, of molecules to allow for read-across i.e. the prediction of toxicity from chemical structure. It covers the scientific basis for this approach to toxicity prediction including the methods to group compounds (structural analogues and / or similarity, mechanism of action) and the tools to achieve this. The approaches to perform read-across within a chemical category are also described. The book will provide concise practical guidance for those wishing to apply these methods (in risk / hazard assessment) and will be illustrated with case studies. Chemical Toxicity Prediction is the first book that addresses the concept of category formation and read-across for toxicity prediction specifically. This topic has really taken off in the past few years due to concerns over dealing with the REACH legislation and also due to the availability of the OECD (Q)SAR Toolbox. Much (lengthy and complex) guidance is available on category formation e.g. from the OECD and, to a lesser extent, the European Chemicals Agency but there is no one single source of information that covers all techniques in a concise user-friendly format. There is a real need for this information as in silico toxicology has come to the fore in recent years, primarily as a result of the EU REACH legislation, but also due to many other drivers e.g. reduction of animal testing, Cosmetics regulation. Category formation is seen as the only practical approach to make rational and transparent predictions for complex (human) toxicological endpoints. The book covers all the areas required to create a robust category and perform read-across.

Toxicological Effects of Veterinary Medicinal Products in Humans - Complete Set (Hardcover): Kevin Woodward Toxicological Effects of Veterinary Medicinal Products in Humans - Complete Set (Hardcover)
Kevin Woodward; Contributions by Peter Silley, Derek Renshaw; Series edited by Tim Marrs
R8,758 Discovery Miles 87 580 Ships in 10 - 15 working days

Toxicological Effects of Veterinary Medicinal Products in Humans is the first definitive guide to discuss the adverse effects of veterinary medicinal products in humans. The chapters focus on occupational safety and consumer issues and examine the circumstances under which exposure is likely to occur. To be in context, it reviews this against the background of adverse health effects from other sources in the veterinary and farming professions. The book examines adverse drug effects reported to regulatory agencies (mainly the FDA's Center for Veterinary Medicine) and then considers a series of individual drugs, including antibiotics, anaesthetics and organophosphorus compounds. The chapters also discuss the fundamental aspects of regulatory issues relating to safety assessment, and examine the manner in which user safety is assessed prior to authorisation/approval and what measures can be taken after authorisation/approval in the light of findings from pharmacovigilance activities. There is growing concern over the issue of antimicrobial resistance and the contribution made by veterinary medicinal products. This too is addressed along with the significance to human health and measures that can be taken to mitigate the effects (if any) of the use of antibiotics in animals e.g. prudent use measures. The book will be an essential resource for medical practitioners in hospitals and general practice, pharmaceutical industry scientists, analysts, regulators and risk managers.

Regulatory Toxicology in the European Union (Hardcover): Tim Marrs, Kevin Woodward Regulatory Toxicology in the European Union (Hardcover)
Tim Marrs, Kevin Woodward; Revised by Roland Solecki; Series edited by Tim Marrs; Edited by (editors-in-chief) Diana Anderson; Contributions by …
R5,281 Discovery Miles 52 810 Ships in 10 - 15 working days

Key areas: Safety and hazards, toxicology, biological sciences, medicinal and pharmaceutical sciences Audience: Researchers in academia and industry and both undergraduate and postgraduate students, regulatory authorities USPs: It will be the only text which comprehensively covers this subject. With the growing body of EU legislation involved in the regulation of chemicals, there is a concomitant need to understand the toxicological principles underlying safety assessments. This will be the first book to cover regulatory toxicology in Europe, and the way that toxicology and the various legislative processes combine to regulate chemical commodities in Europe. Websites to approach to publicise: British Toxicology Society (http://www.thebts.org/) International Union of Toxicology (http://www.iutox.org/) Society of Toxicology (http://www.toxicology.org/)The Organisation for Professionals in Regulatory Affairs (http://www.topra.org/)

Why Do Linguistics? - Reflective Linguistics and the Study of Language (Paperback): Fiona English, Tim Marr Why Do Linguistics? - Reflective Linguistics and the Study of Language (Paperback)
Fiona English, Tim Marr
R713 R529 Discovery Miles 5 290 Save R184 (26%) Ships in 10 - 15 working days

What do we need to know about language and why do we need to know it? This book shows how viewing the world through a linguistics lens can help us to understand how we communicate with each other and why we do it in the ways we do. Above all this book is about noticing. It is about encouraging readers to pay attention to the language that surrounds them. The book addresses fundamental linguistic questions such as: Where do people's beliefs about language come from? Who decides what language we should speak? How do we choose the best way to express what we mean? It introduces a set of practical tools for language analysis and, using examples of authentic communicative activity including overheard conversations, Facebook posts and public announcements, shows how this kind of analysis works and what it can tell us about social interaction. Exploring language and language use from a social, intercultural and multilingual perspective, the authors demonstrate the relevance of linguistics in understanding day-to-day interaction. This book will help readers not only to become informed, active observers of language for its own sake, but also to be able to take on and challenge some of the misconceptions, assumptions and prejudices that so often underlie public discussion of language issues.

Rethinking TESOL in Diverse Global Settings - The Language and the Teacher in a Time of Change (Hardcover): Tim Marr, Fiona... Rethinking TESOL in Diverse Global Settings - The Language and the Teacher in a Time of Change (Hardcover)
Tim Marr, Fiona English
R1,902 Discovery Miles 19 020 Out of stock

What do TESOL teachers actually teach? What do they know about language, about English and the ways it is used in the world? How do they view themselves and their work, and how are they viewed by others? How is TESOL perceived as a profession and as a discipline? How can teachers make the most of the available resources? Can global English really deliver what it seems to promise? These are some of the questions explored in Rethinking TESOL in Diverse Global Settings, a book which examines what we mean when we talk about English language teaching and what we understand the job of an English language teacher to be. Covering diverse teaching environments, from China to Latin America and the Middle East, and from elementary school to university, the authors take a critical look at TESOL by focusing on the actual substance of the subject, language, and attitudes towards it. Through concrete examples from language classrooms, in the form of vignettes and accounts from native speaker and non-native speaker teachers alike, they explore the experiences of teachers worldwide in relation to issues of identity and professionalism, nativeness and non-nativeness, and the pressures of dealing with the expectations with which English has become invested. While recognising the often precarious academic and institutional status of TESOL teachers, the book pulls no punches in challenging those teachers as a whole to become more ambitious in their aims, positioning themselves not as mere skills providers, but language experts, specialists in their subject, members of a legitimate academic discipline. Only then, the authors argue, will TESOL teachers and their work be taken seriously and their expertise recognised.

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