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Regulatory Mechanisms Controlling HIV-1 Induced Immune Activation (Paperback) Loot Price: R717
Discovery Miles 7 170
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Regulatory Mechanisms Controlling HIV-1 Induced Immune Activation (Paperback): Amanda Jewell Chase
Regulatory Mechanisms Controlling HIV-1 Induced Immune Activation (Paperback): Amanda Jewell Chase

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Regulatory Mechanisms Controlling HIV-1 Induced Immune Activation (Paperback)

Amanda Jewell Chase

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Loot Price R717 Discovery Miles 7 170 | Repayment Terms: R67 pm x 12*

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The most widely accepted theory for the massive depletion of CD4] T cells in HIV-1 infection involves depletion of non-infected cells through immune activation. A specialized cell population, the T regulatory cells (Tregs), exists to help limit chronic inflammation by suppressing the immune activation induced by infectious diseases. We used an SIV/pigtailed macaque model of HIV-1 disease to elucidate the role of Tregs in HIV-1-induced depletion of CD4+ T cells in lymphoid tissue during the acute phase of infection. From this model, we learned that Tregs play a significant role in controlling the apoptotic loss of CD4+ T cells resulting from high levels of generalized immune activation. Using assays developed in the macaque model, we next studied the role of Tregs in elite suppressors who are HIaV-1-infected individuals that maintain normal CD4+ T cell counts and control viremia without therapy. The assays developed in our laboratory should be especially useful to the future studies of both virologists and immunologists.


Imprint: VDM Verlag Dr. Mueller E.K.
Country of origin: Germany
Release date: October 2008
First published: October 2008
Authors: Amanda Jewell Chase
Dimensions: 229 x 152 x 4mm (L x W x T)
Format: Paperback - Trade
Pages: 76
ISBN-13: 978-3-639-08889-2
Barcode: 9783639088892
Categories: Promotions
Books > Medicine > General issues
Books > Medicine > General issues > General
LSN: 3-639-08889-1

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