The most widely accepted theory for the massive depletion of CD4] T
cells in HIV-1 infection involves depletion of non-infected cells
through immune activation. A specialized cell population, the T
regulatory cells (Tregs), exists to help limit chronic inflammation
by suppressing the immune activation induced by infectious
diseases. We used an SIV/pigtailed macaque model of HIV-1 disease
to elucidate the role of Tregs in HIV-1-induced depletion of CD4+ T
cells in lymphoid tissue during the acute phase of infection. From
this model, we learned that Tregs play a significant role in
controlling the apoptotic loss of CD4+ T cells resulting from high
levels of generalized immune activation. Using assays developed in
the macaque model, we next studied the role of Tregs in elite
suppressors who are HIaV-1-infected individuals that maintain
normal CD4+ T cell counts and control viremia without therapy. The
assays developed in our laboratory should be especially useful to
the future studies of both virologists and immunologists.
VDM Verlag Dr. Mueller E.K.
|Country of origin:
Amanda Jewell Chase
||229 x 152 x 4mm (L x W x T)
||Paperback - Trade
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