Dibenzothiazepines - Quetiapine, Tianeptine, Clotiapine (Paperback)

Chapters: Quetiapine, Tianeptine, Clotiapine. Source: Wikipedia. Pages: 29. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Quetiapine (pronounced ), marketed by AstraZeneca as Seroquel and by Orion Pharma as Ketipinor, both as an quetiapine fumarate salt of the drug, is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression, and used off-label for a variety of other purposes, including insomnia and anxiety disorders. Annual sales are approximately $4.7 billion worldwide, and $2.9 billion in the U.S. The patent in the U.S., which was set to expire in 2011, received a pediatric exclusivity extension, which pushed its expiration to March 26, 2012. The patent already expired in Canada. Several pharmaceutical companies are now making generic versions of quetiapine. Quepin is a generic version manufactured and marketed by Specifar ABEE, Athens, Greece. Quetiapine (Seroquel) 25 mg tablets, next to US one-cent coin for comparison.Quetiapine is indicated for the treatment of schizophrenia, depressive episodes associated with bipolar disorder, acute manic episodes associated with bipolar I disorder (as either monotherapy or adjunct therapy to lithium or valproate), and maintenance treatment of bipolar I disorder (as adjunct therapy to lithium or divalproex). Quetiapine received its initial indication from the U.S. Food and Drug Administration for treatment of schizophrenia in 1997. In 2004, it received its second indication for the treatment of mania-associated bipolar disorder. It is sometimes used off-label, often as an augmentation agent, to treat conditions such as obsessive-compulsive disorder, post-traumatic stress disorder, restless legs syndrome, autism, alcoholism, depression, Tourette syndrome, and has been used by ph...More: http://booksllc.net/?id=185384