This historic book may have numerous typos and missing text.
Purchasers can download a free scanned copy of the original book
(without typos) from the publisher. Not indexed. Not illustrated.
1909 Excerpt: ...Here the changes in the blood corpuscles are
excluded from the possible cause of the nervous symptoms, much less
of the fatal issue. The venoms of Enhydrimi and Distira, two marine
snakes, contain very little of the haemolytic principles, but are
many times more toxic than that of the most dreaded land snake, the
cobra. One minimal lethal dose of the venom of Enhydrina can
destroy about 9&1; part of the blood of the animal injected
with this venom. (Rogers.) The resistance of the haemolysins is
shown to be much weaker than that of the neurotoxins against peptic
digestion (F lexner and Noguchi). So much for the biological
isolation of the neurotoxins from the haemolysins. The next phase
of this subject is of its chemical isolation, which was first
accomplished by Kyes and later confirmed by von Dunger n and Coca.
Kyes succeeded in isolating venom lecithid by shaking an aqueous
solution of venom with a chloroform solution of lecithin. The venom
lecithid is exclusively haemolytic, but not at all toxic. On
examining the venom solution from which the venom lecithid has been
separated by centrifugalization, Kyes found that the original
toxicity of cobra venom was left in the aqueous portion in
undiminished quantity.' Thus the haemolytic and neurotoxic
principles have been completely separated. The injection of the
venom lecithid in a large quantity does not kill the animal. On the
other hand, the remaining venom solution is no longer haemolytic,
but still highly neurotoxic. Von Dungern and Coca prepared the
lecithid by the same method, but they once found that the venom
solution still contained a certain amount of haemolysins, while
another time the removal of haemolysins was complete. Morgenroth
prepared venom lecithid by a slightly modified method, in...
|Country of origin:
Carnegie Institution of Washington
||246 x 189 x 9mm (L x W x T)
||Paperback - Trade
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