The science and applied approaches of enzyme inhibition in drug
discovery and development
Offering a unique approach that includes both the pharmacologic
and pharmaco-kinetic aspects of enzyme inhibition, "Enzyme
Inhibition in Drug Discovery and Development" examines the
scientific concepts and experimental approaches related to enzyme
inhibition as applied in drug discovery and drug development.
With chapters written by over fifty leading experts in their
fields, "Enzyme Inhibition in Drug Discovery and Development"
fosters a cross-fertilization of pharmacology, drug metabolism,
pharmacokinetics, and toxicology by understanding the "good"
inhibitions--desirable pharmacological effects--and "bad"
inhibitions--drug-drug interactions and toxicity. The book
The drug discovery process, including drug discovery strategy,
medicinal chemistry, analytical chemistry, drug metabolism,
pharmacokinetics, and safety biomarker assessment
The manipulations of drug metabolizing enzymes and transporters
as well as the negative consequences, such as drug-drug
The inhibition of several major drug target pathways, such as
the GPCR pathway, the NFkB pathway, and the ion channel pathway
Through this focused, single-source reference on the
fundamentals of drug discovery and development, researchers in drug
metabolism and pharmacokinetics (DMPK) will learn and appreciate
target biology in drug discovery; discovery biologists and
medicinal chemists will also broaden their understanding of
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