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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine

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Prostaglandin E1 - New Aspects on Pharmacology, Metabolism and Clinical Efficacy (Paperback) Loot Price: R1,871
Discovery Miles 18 710
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Prostaglandin E1 - New Aspects on Pharmacology, Metabolism and Clinical Efficacy (Paperback): Curt Diehm, Helmut Sinzinger,...
Prostaglandin E1 - New Aspects on Pharmacology, Metabolism and Clinical Efficacy (Paperback): Curt Diehm, Helmut Sinzinger,...

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Prostaglandin E1 - New Aspects on Pharmacology, Metabolism and Clinical Efficacy (Paperback)

Curt Diehm, Helmut Sinzinger, Waltraud Rogatti

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List price R1,971 Loot Price R1,871 Discovery Miles 18 710 | Repayment Terms: R174 pm x 12* You Save R100 (5%)

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Although prostaglandin El (PGE ) has been clinically available for a long 1 time, only in recent years has its effectiveness in peripheral arterial occlusive disease been confirmed in controlled studies. Not surprisingly, the favour- able results achieved both in patients with critical limb ischaemia and in those with intermittent claudication has stimulated research activities into the clinical pharmacology of this prostaglandin. As a consequence of these efforts, exciting new findings have revealed that PGE has anti thrombotic , endothelium-stabilizing and leucocyte-stabi- 1 lizing properties as well as effects on lipid metabolism, all of which, quite apart from its well-known anti-aggregating and vasodilator effects, may add to the clinical efficacy of the substance. New data have also been gathered on the metabolism of PGE most b notably the detection of 13,14-dihydro-PGE a metabolite which was b recently isolated in humans following the administration of PGE . Being 1 biologically active, the pharmacodynamic spectrum of 13,14-dihydro-PGE 1 very closely resembles that of PGE . This finding may help to explain the 1 efficacy of PGE despite its rapid metabolization when given intravenously.

General

Imprint: Springer-Verlag
Country of origin: Germany
Release date: 1992
First published: 1991
Editors: Curt Diehm • Helmut Sinzinger • Waltraud Rogatti
Dimensions: 235 x 155 x 7mm (L x W x T)
Format: Paperback
Pages: 117
ISBN-13: 978-3-540-54524-8
Barcode: 9783540545248
Categories: Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Books > Medicine > Other branches of medicine > Pharmacology
Books > Medicine > Other branches of medicine > Pharmacology > General
Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > Metabolism
LSN: 3-540-54524-7

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