As opposed to other books on the topic, this volume is unique in
also covering emerging transporter targets. Following a general
introduction to the importance of targeting transporter proteins
with drugs, the book systematically presents individual transporter
classes and explains their pharmacology and physiology. The text
covers all transporter families with known or suspected importance
as drug targets, including neurotransmitter transporters, ABC
transporters, glucose transporters and organic ion transporters.
The final part discusses recent advances in structural studies of
transport proteins, assay methods for transport activity, and the
systems biology of transporters and their regulation. With its
focus on drug development issues, this authoritative overview is
required reading for researchers in industry and academia targeting
transport proteins for the treatment of disease.
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