Hepatitis B virus (HBV) infection is a major public health problem
worldwide and HB vaccine is the most effective measure to prevent
HB virus infection. An initial anti-HBs threshold value of 10
mIU/ml or greater is considered generally protective. However, the
protective antibodies induced by HB vaccine wane gradually over
time and may reach very low or even undetectable level. Immunologic
studies indicated that HB vaccine induces immunologic memory and
memory B cells can generate a rapid and vigorous anamnestic
anti-HBs response upon re-exposure to HBsAg. Accordingly, long-term
protection after vaccination and the possible need for booster dose
of vaccine has remained controversial. To answer this question, we
used two different approaches to determine the duration of
protection provided by HB vaccine. Four different studies will be
presented: a) Seroprotection of HB vaccine and need for booster
dose: A meta-analysis b) Long-term protection provided by HB
vaccine and need for booster dose: A meta-analysis c)
Capture-recapture method for assessing publication bias. d)
MetaPlot: A novel Stata graph for assessing heterogeneity at a
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