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Arachidonate 5-lipoxygenase (5-lipoxygenase, 5-LO or Alox5) is a
member of the lipoxygenase family of enzymes. It transforms EFAs
into leukotrienes and is a current target for pharmaceutical
intervention in a number of diseases.Lipoxygenases (EC 1.13.11.-)
are a family of iron-containing enzymes that catalyse the
dioxygenation of polyunsaturated fatty acids in lipids containing a
cis, cis-1,4- pentadiene structure. It catalyses the following
reaction: fatty acid + O2 = fatty acid hydroperoxide.Lipoxygenases
are found in plants, animals and fungi. Products of lipoxygenases
are involved in diverse cell functions
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