This study is the first detailed analysis of Candida infections in
burn patients in an Indian hospital. Burn patients are never
subjected to fungal culture or given antifungals unless oral thrush
develops. All attention goes to treat life threatening gram-
negative bacterial septicemia. Often there is no significant
bacterial culture positivity, still the patient deteriorates and
dies. Study suggests that in such instances, patient might be
suffering from fungal septicemia. This study is an attempt,
expected to lead to better clinical management of burn patients.
Interactions occurring between various bacteria and fungi in the
burn wound are also analyzed, which may altogether alter the
clinical prognosis of the patient. In agreement with earlier in
vitro studies, it is observed that Pseudomonas significantly
inhibits growth of Candida in vivo in the burn wound, either alone
or in combination with other bacteria suggesting that Pseudomonas
has an inhibitory effect on the growth of Candida. Results also
suggest the involvement of some unknown genes and transcription
factors in causing azole resistance in intrinsically resistant C.
albicans clinical isolates.
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