The systematic identification and characterization of proteins and proteomes is one of the major interdisciplinary research areas of the life sciences in the post-genomic era. One of the primary goals of current proteomic research is the description of the composition, dynamics, and connections of the multi-protein "modules" and "machineries" that perform a wide range of biological functions in the cell. Proteomic Biology Using LC-MS: Large Scale Analysis of Cellular Dynamics and Function examines the latest LC-MS technologies in depth and explores their application to the analysis of the dynamic aspects of cellular function. After an overview of proteomics and proteomic technologies, it covers:
The basic aspects of LC-MS technology, including the principle of the method and assembly of the LC-MS system
Integrated LC-based MS methodologies coupled with quantitative methodologies and/or bioinformatics
The most recent applications, such as the analyses of signal transduction complexes following stimulation of cells and the analysis of the dynamic processes of ribosome biogenesis
A new concept, the "Dynamome," or the expression of a comprehensive molecular set that participates in the whole dynamic process of a series of cellular events
Detailed experimental examples help readers explore various applications in action. With comprehensive coverage of LC-MS technologies applicable to the analysis of dynamic cellular functions in proteomic scale, this is a unique reference for investigators and laboratory staffs in academic institutions and industries. It is also a valuable resourcefor students as well as for scientists in other fields who want to bridge the gap between their specialties and proteomic biology.
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The systematic identification and characterization of proteins and proteomes is one of the major interdisciplinary research areas of the life sciences in the post-genomic era. One of the primary goals of current proteomic research is the description of the composition, dynamics, and connections of the multi-protein "modules" and "machineries" that perform a wide range of biological functions in the cell. Proteomic Biology Using LC-MS: Large Scale Analysis of Cellular Dynamics and Function examines the latest LC-MS technologies in depth and explores their application to the analysis of the dynamic aspects of cellular function. After an overview of proteomics and proteomic technologies, it covers:
The basic aspects of LC-MS technology, including the principle of the method and assembly of the LC-MS system
Integrated LC-based MS methodologies coupled with quantitative methodologies and/or bioinformatics
The most recent applications, such as the analyses of signal transduction complexes following stimulation of cells and the analysis of the dynamic processes of ribosome biogenesis
A new concept, the "Dynamome," or the expression of a comprehensive molecular set that participates in the whole dynamic process of a series of cellular events
Detailed experimental examples help readers explore various applications in action. With comprehensive coverage of LC-MS technologies applicable to the analysis of dynamic cellular functions in proteomic scale, this is a unique reference for investigators and laboratory staffs in academic institutions and industries. It is also a valuable resourcefor students as well as for scientists in other fields who want to bridge the gap between their specialties and proteomic biology.
Imprint | John Wiley & Sons |
Country of origin | United States |
Release date | November 2007 |
Availability | Our supplier does not have stock of this product at present, but they do have demand for it and we can create a special order for you. Alternatively, if you add it to your wishlist we will send you an email message should it become available from stock. |
First published | 2008 |
Authors | N. Takahashi |
Dimensions | 242 x 168 x 18mm (L x W x T) |
Format | Hardcover |
Pages | 264 |
ISBN-13 | 978-0-471-66258-7 |
Barcode | 9780471662587 |
Categories | |
LSN | 0-471-66258-5 |