This book deals with basic and clinical aspects of monoamine
oxidase (MAO) subtypes A and B highlighting its importance in
neurological and psychiatric diseases. Consequently the therapeutic
actions of MAO-A and -B inhibitors in Parkinsona (TM)s disease (PK)
and depression are the focus of several chapters. As MAO is the
basis of the development of the "oxidative stress hypothesis" of
PD, several chapters are devoted to iron and iron-induced oxidative
stress in various experimental studies and clinical conditions.
Based on these findings, new compounds have been developed which
not only block MAO, but are in addition, either inhibitors of
acetylcholine esterase or have iron chelating properties. The
aspect of "preclinical" and "clinical" neuro protection as well as
MAO neuroprotection are additional topics covered in this book.
MAO, iron and neuroprotection are seen in the framework of general
anti Parkinsona (TM)s therapy with chapters on levodopa,
dopaminergic receptor agonists and clinical issues.
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