Toxicology has made tremendous strides in the sophistication of the
models used to identify and understand the mechanisms of agents
that can harm or kill humand and other higher organisms.
Non-animals or in vitro models started to gain significant use in
the 1960s. As a result of the increased concern over animal
welfare, economic factors, and the need for greater sensitivity and
understanding of mechanisms, interest in in vitron models has
risen. This volume demonstrates that there now exists a broad range
of in vitro models for use in either identifying or understanding
most forms of toxicity. The availability of in vitro models spans
both the full range of endpoints (irritation, sensitization,
lethality, mutagenicity, and devlopmental toxicity) and the full
spectrum of target organ systems (skin, eye, heart, liver, kidney,
nervous system, etc.). Chapters are devoted to each of these
speciality areas from a perspective of presenting the principal
models and their uses and limitations.; Chapters that overview the
principles involved in the general selection and use of models, and
that address the issues of safety concerns and regulatory
acceptance of these methods are also included. Gad; Shayne C.
|Country of origin:
Shayne C Gad
||Electronic book text
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