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Anti-HIV Bioadhesive Microencapsulated Vaginal Gel (Paperback) Loot Price: R1,618
Discovery Miles 16 180
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Anti-HIV Bioadhesive Microencapsulated Vaginal Gel (Paperback): Arkendu Chatterjee, Benoy Brata Bhowmik, K. Gauthaman

Anti-HIV Bioadhesive Microencapsulated Vaginal Gel (Paperback)

Arkendu Chatterjee, Benoy Brata Bhowmik, K. Gauthaman

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Loot Price R1,618 Discovery Miles 16 180 | Repayment Terms: R150 pm x 12*

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The aim of this study was to develop and evaluate Zidovudine (AZT) loaded microparticulated bioadhesive vaginal gel (AZMBVG) in order to obtain a controlled-releasing, in order to obtain a controlled-release system for treatment of AIDS. AZT microparticle AZMCs was prepared by O/O single emulsion solvent evaporation method (II) and evaluated for encapsulation efficiency, drug loading, surface morphology and invitro drug release profiles and drug release mechanism and optimized. To achieve second objective, optimized AZMC4 were encompassed in bioadhesive gel to form AZMBVGs by cold mechanical method and compared with the bioadhesive vaginal gel (BVG1) without microcapsule. The optimized microcapsules were incorporated in bioadhesive gel prepared using different bioadhesive polymer evaluated the gel for the encapsulation efficiency, drug loading, invitro release profiles and drug release kinetics, spreadability, extrudibility, bioadhesion, vaginal irritancy and pharmacokinetics study by invivo methods by using New Zealand white female rabbit model. A comprehensive protocol, for the AZMBVG was developed successfully. Further research in this area will be significant outcome for AIDS

General

Imprint: Lap Lambert Academic Publishing
Country of origin: Germany
Release date: June 2012
First published: June 2012
Authors: Arkendu Chatterjee • Benoy Brata Bhowmik • K. Gauthaman
Dimensions: 229 x 152 x 13mm (L x W x T)
Format: Paperback - Trade
Pages: 224
ISBN-13: 978-3-659-14998-6
Categories: Books > Medicine > Other branches of medicine
Books > Medicine > Other branches of medicine > Pharmacology
Books > Medicine > Other branches of medicine > Pharmacology > General
LSN: 3-659-14998-5
Barcode: 9783659149986

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