Human Haplotypes - Human Y-DNA Modal Haplotypes, Human Multigene Haplotypes, Y-Chromosomal Aaron, A30-Cw5-B18-Dr3-Dq2, HLA A1-B8-Dr3-Dq2 (Paperback)

Chapters: Human Y-Dna Modal Haplotypes, Human Multigene Haplotypes, Y-Chromosomal Aaron, A30-Cw5-B18-Dr3-Dq2, Hla A1-B8-Dr3-Dq2, Niall of the Nine Hostages, Descent From Genghis Khan, Somerled, Atlantic Modal Haplotype, Haplotype 35. Source: Wikipedia. Pages: 76. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Multi-gene haplotype, humanHLA A30-Cw5-B18-DR3-DQ2 (A30:: DQ2 ) is a multigene haplotype that extends across a majority of the major histocompatibility complex on human chromosome 6 . A multigene haplotype is a set of inherited alleles covering several genes, or gene-alleles. Long haplotypes, like A30:: DQ2, are generally the result of descent by common ancestry . As haplotypes increase in size, Chromosomal recombination fragments them in a generation dependent process.A30:: DQ2 can be written in an extended form covering the major histocompatibility loci as follows: HLA A*3002 Cw*0501 B*1801 DRB1*0301 DQA1*0501 DQB1*0201.There are several composite haplotypes, A30-Cw5-B18 and a variant A30-CBL-B18 comprise A30:: B18, there is also the B18-DR3 component and the HLA DR3-DQ2.5 . Other haplotypes such as Cw5-B16-DR3 or B8-DR3-DQ2.5 have been presented in the literature.A dozen inflammatory diseases of the immune system can attribute some risk to the haplotype. Some disease like coeliac disease primarily associate with certain genes. While other diseases, like type 1 diabetes may have several, highly different, genes that attribute risk. Still other diseases, like myasthenia gravis have undetermined linkage to the haplotype.Further information: HLA DR3-DQ2 Haplotypes of A30-B18 or Cw5-B18 have been studied (see allelefrequencies.net and IHWC 1991). Despite that large areas of Northern Africa have not been studies by HLA, A30:: DQ2 appears to have originate southwest of is current mode in Sardinia. Gomez-Casado et al. (2000) o