Pathophysiology - Pathophysiology of Multiple Sclerosis, Pathophysiology of Chronic Fatigue Syndrome, Pathophysiology of Hypertension, Ectasia (Paperback)

Chapters: Pathophysiology of Multiple Sclerosis, Pathophysiology of Chronic Fatigue Syndrome, Pathophysiology of Hypertension, Ectasia. Source: Wikipedia. Pages: 70. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Multiple sclerosis is defined as a disease in which the myelin (a fatty substance which covers the axons of nerve cells) degenerates, leaving a special kind of lesions in the brain and spinal cord of the patients. This definition is used implicitly for MS when using the McDonald criteria that says "the only proved diagnosis of MS can be made upon autopsy, or occasionally upon biopsy, where lesions typical of MS can be directly detected through standard histopathological techniques." Unfortunately they do not define what the "lesions typical of MS" are. The Pathophysiology of multiple sclerosis is complex and still under investigation. At least five characteristics are present in CNS tissues of MS patients: Inflammation beyond classical white matter lesions, Intrathecal Ig production with oligoclonal bands, An environment fostering immune cell persistence, Follicle-like aggregates in the meninges and a disruption of the blood-brain barrier also outside of active lesions. Apart of the usually known white matter demyelination, also the cortex and deep gray matter (GM) nuclei are affected, together with diffuse injury of the normal-appearing white matter.. MS is active even during remission periods. GM atrophy is independent of the MS lesions and is associated with physical disability, fatigue, and cognitive impairment in MS Demyelinization by MS. The Kluver-Barrera colored tissue show a clear decoloration in the area of the lesion (Original scale 1:100) Demyelinization by MS. The CD68 colored tissue shows several Macrophages in the area of the lesion. Original scale 1:100Demyelinat...More: http: //booksllc.net/?id=493009