Sulfonamide Antibiotics - Sulfonamide, Sulfamethoxazole, Sulfadimidine, Prontosil, Elixir Sulfanilamide, Sulfadoxine, Sulfacetamide (Paperback)

Purchase includes free access to book updates online and a free trial membership in the publisher's book club where you can select from more than a million books without charge. Chapters: Sulfonamide, Sulfamethoxazole, Sulfadimidine, Prontosil, Elixir Sulfanilamide, Sulfadoxine, Sulfacetamide, Silver Sulfadiazine, Sulfaguanidine, Sulfapyridine, Sulfaquinoxaline, Sulfamethizole, Sulfisomidine, Mafenide, Sulfafurazole, Sulfadiazine, Sulfametrole, Sulfadimethoxine, Sulfametoxydiazine, Aldesulfone Sodium, Sulfaphenazole, Sulfathiazole, Sulfamerazine, Sulfathiourea, Sulfametomidine, Sulfamazone, Sulfamoxole, Phthalylsulfathiazole, Sulfamethoxypyridazine, Sulfaperin, Succinylsulfathiazole, Sulfalene, Sulfatolamide, Sulfadicramide. Excerpt: Aldesulfone sodium (or sulfoxone ) is an antibiotic used in the treatment of leprosy . Sulfoxone sodium was introduced in Japan in 1948. References (URLs online) A hyperlinked version of this chapter is at Bottles of Elixir Sulfanilamide Elixir sulfanilamide was an improperly prepared sulfanilamide medicine that caused mass poisoning in the United States in 1937. It caused the deaths of more than 100 people. The public outcry caused by this incident and other similar disasters led to the passing of the 1938 Federal Food, Drug, and Cosmetic Act . History Aside from the Pure Food and Drug Act of 1906 and the Harrison Act of 1914 banning the sale of some narcotic drugs, there was no federal regulatory control ensuring the safety of new drugs until Congress enacted the 1938 Food, Drug, and Cosmetic Act in response to the elixir sulfanilamide poisoning crisis. In 1937, S. E. Massengill Company, a pharmaceutical manufacturer, created a preparation of sulfanilamide using diethylene glycol (DEG) as a solvent, and called the preparation "Elixir Sulfanilamide." DEG is poisonous to humans, but Harold Watkins, the company's chief pharmacist and chemist, was not aware of this (although it was known at the time). Watkins simply added raspberry ...