This study of basic thrombosis research and its clinical
applications critically evaluates traditional strategies for
treating patients with thrombo-embolic complications. The authors
question the assumption that platelets are the predominant factor
in the development of arthero-sclerosis. Indeed, these studies show
that monocytes and vessel wall factors may also play an important
role. The author's conclusion is that a new therapeutic approach
should aim at influencing these pathways. The book also discusses
the fact that the radio-labelling of platelets has been established
as an accepted laboratory method for evaluating the interaction of
the platelets with the vessel wall. This has important consequences
for the in vivo quantification of platelet deposits and the testing
of various antithrombotic drugs.
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