Methods in Toxicology, v.1; Pt.A - In Vitro Biological Systems (Hardcover)

There is a pressing need among researchers involved in toxicologic investigation for a series of publications that organizes and presents information on the latest experimental methodologies. To address the needs of researchers in toxicology, toxicologic pathology, pharmacology, and clinical biochemistry, this new serial - "Methods in Toxicology" - provides comprehensive descriptions of state-of-the-art methods for evaluating drug and chemical toxicity. Thematic volumes focus on mechanistic approaches to the study of toxicity both "in vitro" and "in vivo", taking advantage of the recent advances in the biological and chemical sciences that allow closer scrutiny of the mechanisms by which chemical agents cause organismic or cellular damage. Each volume begins with an introductory chapter that offers a broad guide to the application of methods addressed in that volume.;Subsequent chapters contain detailed descriptions of research protocols, accessible both to experts and those new to toxicologic investigation. Included in each chapter are clearly defined procedures, discussions of limitations of the method, comparative considerations (species, sex, strain), interpretations of results