Materia Medica and Therapeutics. (Paperback)

This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1906. Excerpt: ... in ulcers, hemorrhoids, and fistula. Solutions of from 2 to 10 per cent. are applied in coryza, hay fever, laryngitis, and nasal hemorrhage. Two per cent. solutions applied to the urethra two or three times secure anaesthesia. In the eye as a mydriatic; in conjunctivitis and corneal ulcers. COLCHICUM (CORM AND SEED). Sources.--Colchici cormus and colchici semen are the corm and seed of Colchicum autumnale, a plant indigenous to Europe. On assay, the corm should yield not less than 35 per cent. and the seed not less than 55 per cent. of the alkaloid, colchicine.. The Official Preparations of Colchicum. Extractum Colchici Cormi (Extract of Colchicum Corm).--Dose, I to 2 grs. (0.03 to 0.12 gm.). Fluidextractum Colchici Seminis (Fluidextract of Colchicum Seed).--Dose, 1 to 5 n (0.06 to 0.30 c.c). Tinctura Colchici Seminis (Tincture of Colchicum Seed).--Dose, 5 to 15 nx (0.30 to 1 c.c). Vinum Colchici Seminis (Wine of Colchicum Seed).--Dose, 30 to 60 t (2 to 4 c.c). Colchicine is official. Dose, to T7 gr. (0.00025 to 0.001 gm.). Symptoms.--In therapeutic doses colchicum produces no symptoms. Poisoning.--The effects do not appear for some time and are due to gastroenteritis. They are pains in the abdomen, nausea, vomiting, and diarrhoea, with bloody stools. Symptoms of collapse follow; there is muscular weakness; a paralysis beginning at the extremities and extending upward involving the respiratory centre and causing death. Consciousness remains till the end, although there may be mental confusion and vertigo. The symptoms seen aside from those of gastrointestinal irritation may be due to this influence or, as is more probable, to depression and paralysis of the central nervous system. Uses.--Colchicum is used empirically as an alterative and the little knowl...