Frank's Sign (Paperback)

High Quality Content by WIKIPEDIA articles Frank's sign or Frank sign is a diagonal ear lobe crease (ELC) extending diagonally from the tragus across the lobule to the rear edge of the auricle. It has been hypothesised that Frank's sign is a sign of cardiovascular disease and/or diabetes. Some studies have described Frank's sign as a marker of cardiovascular disease but not linked to the severity of the condition. In contrast, other studies have rebutted any association between Frank's sign and coronary artery disease. However, researchers do agree that the presence of these creases probably isn't significant in Native Americans and Eastern Asians. Heart disease or cardiovascular diseases is the class of diseases that involve the heart or blood vessels (arteries and veins). While the term technically refers to any disease that affects the cardiovascular system (as used in MeSH C14), it is usually used to refer to those related to atherosclerosis (arterial disease). These conditions have similar causes, mechanisms, and treatments.