Applications of Proteomics to Cell Signaling (Hardcover)

The field of proteomics has had a tremendous impact on our understanding of biological systems. While proteomics encompasses multiple approaches, the application of mass spectrometry-based techniques has generated large, information-rich data sets that have enabled a much clearer understanding of areas such as cell signaling. For example, protein post-translational modifications such as phosphorylation are critically involved in signal transduction in almost all biological systems; much progress has been made to identify these protein alterations during signal transduction. This work focuses specifically on the application of these approaches to understanding signaling in biological systems.