Handbook of pharmacokinetics - Toxicity assessment of chemicals (Hardcover)

This introduction to pharmacokinetics has been designed to lead the novice to a sufficiently advanced level to design the appropriate experimental studies as part of the safety evaluation of chemicals. It will be of value to those involved in the development and toxicity assessment of chemicals.;The author defines the mechanisms of drug absorption, and influencing factors such as dissolution, gastric emptying and blood flow, as well as modifying factors such as endogenous and exogenous substances. He examines the nature of first-pass effect in the pulmonary, gastrointestinal and hepatic systems, and present animal and clinical studies showing determination of first-pass effect. Further sections of the text survey distribution circulation proteins, tissue distribution, tissue clearance, kinetic data and clinical pharmacokinetics.