Cyp7b1 (Paperback)

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. 25-hydroxycholesterol 7-alpha-hydroxylase is an enzyme that in humans is encoded by the CYP7B1 gene.This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis.