Dio2 (Paperback)

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Type II iodothyronine deiodinase is an enzyme that in humans is encoded by the DIO2 gene.The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves' disease and thyroid adenomas.