Hk1 (Paperback)

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Hexokinase-1 is an enzyme that in humans is encoded by the HK1 gene.Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific.