Small Nucleolar RNA Snord15 (Paperback)

High Quality Content by WIKIPEDIA articles! SNORD15 (also known as U15) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. U15 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. U15 is predicted to guide the 2'O-ribose methylation of 28S ribosomal RNA (rRNA) residue A3764.