Ssri Discontinuation Syndrome (Paperback)

High Quality Content by WIKIPEDIA articles! SSRI discontinuation syndrome (also known as SSRI withdrawal syndrome or SSRI cessation syndrome) is a cluster of symptoms syndrome that can occur following the interruption, dose reduction, or discontinuation of SSRI (selective serotonin reuptake inhibitor) or SNRI antidepressant medications. The condition often begins between 24 hours to 10 days after reduction in dosage or complete discontinuation, depending on the elimination half-life of the drug and the patient's metabolism. The prescribing labels of some SSRIs note the possibility of "intolerable" discontinuation reactions. Some patients have extreme difficulty discontinuing use of SSRI drugs. The existence of the syndrome is somewhat controversial, however, there are double-blind placebo-controlled studies that demonstrate statistically significant results for the discontinuation of an SSRI used in monotherapy.