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Antitargets and Drug Safety (Hardcover) Loot Price: R2,505
Discovery Miles 25 050
You Save: R612 (20%)
Antitargets and Drug Safety (Hardcover): Laszlo Urban, Vinod Patel, Roy J. Vaz

Antitargets and Drug Safety (Hardcover)

Laszlo Urban, Vinod Patel, Roy J. Vaz

Series: Methods and Principles in Medicinal Chemistry

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List price R3,117 Loot Price R2,505 Discovery Miles 25 050 | Repayment Terms: R233 pm x 12* You Save R612 (20%)

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With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusing on hepatotoxicity in drug safety, cardiovascular toxicity and signaling effects via kinase and GPCR anti-targets. In the final section, several case studies of recently developed drugs illustrate how to prevent anti-target effects and how big pharma deals with them if they occur. The more recent field of systems pharmacology has gained prominence and this is reflected in chapters dedicated to the utility in deciphering and modeling anti-targets. The final chapter is concerned with those compounds that inadvertently elicit CNS mediated adverse events, including a pragmatic description of ways to mitigate these types of safety risks. Written as a companion to the successful book on antitargets by Vaz and Klabunde, this new volume focuses on recent progress and new classes, methods and case studies that were not previously covered.

General

Imprint: Wiley-VCH Verlag GmbH
Country of origin: Germany
Series: Methods and Principles in Medicinal Chemistry
Release date: April 2015
Editors: Laszlo Urban • Vinod Patel • Roy J. Vaz
Dimensions: 244 x 172 x 31mm (L x W x T)
Format: Hardcover
Pages: 528
ISBN-13: 978-3-527-33511-4
Categories: Books > Professional & Technical > Industrial chemistry & manufacturing technologies
Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry
Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology
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LSN: 3-527-33511-0
Barcode: 9783527335114

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