The Chemistry of Synthetic Drugs (Paperback)

This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1911 Excerpt: ...which is 6-7 dimethoxy-2 methyl-3-4dihydro-isoquinolinium chloride, has been introduced into practice under the name "Lodal"--1 It causes a rise of blood pressure, and renders the heart-beat slower and stronger. Other pressor substances which have been obtained from isoquinoline alkaloids will be considered in the next chapter. It is of interest to note that the N-methyl derivatives of tetrahydro-isoquinoline (narcotine, laudanosine, and hydrastine) are convulsant poisons, while those derived from dihydroisoquinoline (cotarnine, "Lodal," and hydrastinine) are not. This relation does not hold for those derivatives, such as papaverine, which contain no methyl group attached to the nitrogen. 1 Wolloome and Pyman, English Patent (1909), 314. CHAPTER IX ADRENALINE AND OTHER DERIVATIVES OF ETHYLAMINE Within recent years, a large number of ethylamine derivatives, possessing powerful physiological action, have been isolated from various plant and animal sources. Many of these are derivatives and have the property of producing effects very similar to those produced by stimulation of the sympathetic nervous system, one of the most notable of these being rise of blood pressure. Para-hydroxyphenylethylamine is present in aqueous extracts of ergot, and other closely related substances are also found in various plants, but the most important compound of this class principle which has been isolated from the suprarenal glands. It Mras first obtained in the impure condition by Abel and Crawford, in 1897,1 and in a more pure condition as the benzoyl derivative by Abel; in 1899.2 It was called epinephrine by these investigators, and it was also isolated by von Firrth,8 who gave it the name suprarenine. The name adrenaline was first given to it by Takamiue, ...