After the discovery of milk fat globule-epidermal growth
factor-factor 8 (MFG-E8) about two decades ago, a new era of
delineating its potential beneficial role in several inflammatory
diseases has begun to spout from the bench to translational
research. In MFG-E8 and Inflammation, the editor and contributors
have gathered a remarkable collection covering novel discoveries on
the rapidly growing field of MFG-E8 and Inflammation which includes
not only the findings from their individual lobotomies, but also
from a host of pioneering researchers of this field. MFG-E8 and
Inflammation starts by describing the origin, structure,
expression, functions and regulation of MFG-E8, and then continues
thoughtfully exploring its potentiality as a marker for apoptotic,
stressed and activated cells. The topics cover the cellular and
physiological function of MFG-E8, especially its role in efficient
phagocytosis of apoptotic cells, intestinal barrier function, blood
cell homeostasis and coagulation, and in the maintenance of the
intact vascular system. The role of MFG-E8 in macrophages,
neutrophils, lymphocytes, dendritic cells, platelets, as well as
non-hematopoietic cells is adequately described in the book. The
chapters also contain several lucid discussions on the recent
discoveries of the roles of MFG-E8 in the autoimmune diseases,
sepsis, tissue ischemia-reperfusion, hemorrhage, inflammatory bowel
diseases, acute lung injury, asthma, lung fibrosis, stroke, prion
diseases and Alzheimer s diseases with the potential focus on
elucidating novel mechanistic pathways. MFG-E8 and Inflammation is
an indispensable resource for scientists and clinical researchers
working on fundamental or applied aspects of MFG-E8 pathobiology.
This book explores, dissects and reviews several noteworthy
findings and striking future perspectives which not only rewrite
the disease pathophysiology, but also update our understanding
towards attaining novel therapeutic potentials against various
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