Proteinase and Peptidase Inhibition - Recent Potential Targets for Drug Development (Hardcover)

Cellular proteinases and their physiological role in normal and disease states have been the subject of great interest over recent decades. Specific protease inhibitors are exploited at present both as tools in unravelling the role of individual proteinases in particular cellular processes and for the development of chemotherapeutic agents for the treatment of various disorders. Proteinase and Peptidase Inhibition presents a series of up-to-date progress reports on the characterisation of a wide range of cellular proteinases whose inhibitors may hold the key to the development of new drugs.
Introductory chapters deal with the broad enzyme classes, inhibitor types and regulatory mechanisms governing proteinase activity. The target enzymes themselves, together with all aspects of their inhibition and inhibitor design, are comprehensively described in each of the following chapters. The classification of target enzymes by structural similarity, rather than by pharmacological effects, provides a new and coherent platform for understanding how inhibition of different targets can lead to the same therapeutic outcomes.
This is a valuable reference book that will appeal to both academic and industrial researchers in the fields of medicinal chemistry, drug design and development, pharmacology, biochemistry, and molecular and cell biology.

eBook available with sample pages: 0203219171