Transition metals open up new opportunities for synthesis, because
their means of bonding and their reaction mechanisms differ from
those of the elements of the s and p blocks. In the last two
decades the subject has mushroomed - established reactions are
seeing both technical improvements and increasing numbers of
applications, and new reactions are being developed. The
practicality of the subject is demonstrated by the large number of
publications coming from the process development laboratories of
pharmaceutical companies, and its importance is underlined by the
fact that three Nobel prizes have been awarded for discoveries in
this field in the 21st Century already.
"Organic Synthesis Using Transition Metals, 2nd Edition"
considers the ways in which transition metals, as catalysts and
reagents, can be used in organic synthesis, both for pharmaceutical
compounds and for natural products. It concentrates on the
bond-forming reactions that set transition metal chemistry apart
from "classical" organic chemistry. Each chapter is extensively
referenced and provides a convenient point of entry to the research
literature. Topics covered include: introduction to transition
metals in organic synthesiscoupling reactionsC-H
activationcarbonylative coupling reactionsalkene and alkyne
insertion reactionselectrophilic alkene and alkyne
complexesreactions of alkyne complexescarbene complexesh3- or
p-allyl -allyl complexesdiene, dienyl and arene
complexescycloaddition and cycloisomerisation reactions
For this second edition the text has been extensively revised
and expanded to reflect the significant improvements and advances
in the field since the first edition, as well as the large number
of new transition metal-catalysed processes that have come to
prominence in the last 10 years - for example the extraordinary
progress in coupling reactions using "designer" ligands, catalysis
using gold complexes, new opportunities arising from metathesis
chemistry, and C-H activation - without neglecting the well
established chemistry of metals such as palladium.
"Organic Synthesis Using Transition Metals, 2nd Edition" will
find a place on the bookshelves of advanced undergraduates and
postgraduates working in organic synthesis, catalysis, medicinal
chemistry and drug discovery. It is also useful for practising
researchers who want to refresh and enhance their knowledge of the
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