Medical Genetics - Genetic Disorder, Gene Therapy, Heritability of Autism, Paternal Age Effect, List of Geneticists, Full Genome Sequencing (Paperback)

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Pages: 78. Chapters: Genetic disorder, Gene therapy, Heritability of autism, Paternal age effect, List of geneticists, Full genome sequencing, Preimplantation genetic diagnosis, Heritability of IQ, Medical genetics of Jewish people, Adeno associated virus and gene therapy of the human retina, Genetic testing, Oncogenomics, Inborn error of metabolism, Nutritional genomics, DECIPHER, HumGen, Genetic counseling, 1q21.1 deletion syndrome, Genetic Information Nondiscrimination Act, GRaPH-Int, Population stratification, 1q21.1 duplication syndrome, Genetic screen, COSMIC cancer database, Repoxygen, Savior sibling, Databases for oncogenomic research, Pseudodeficiency alleles, Substrate reduction therapy, Mutalyzer, Biodistribution, Functional cloning, Preimplantation genetic haplotyping, Singleton Merten syndrome, Therapeutic gene modulation, Predictive testing. Excerpt: The heritability of autism is the proportion of autism that can be explained by genetic variation; if the heritability of a condition is high, then the condition is considered to be primarily genetic. Autism has a strong genetic basis, although the genetics of autism is complex and it is unclear whether autism spectrum disorder (ASD) is explained more by multigene interactions or by rare mutations with major effects. Early studies of twins estimated the heritability of autism to be more than 90%; in other words, that 90% of the differences between autistic and non-autistic individuals is due to genetic effects. This may be an overestimate; new twin data and models with structural genetic variation are needed. When only one identical twin is autistic, the other often has learning or social disabilities. For adult siblings, the risk of having one or more features of the broader autism phenotype might be as high as 30%, much higher than the risk in controls. Genetic linkage analy...