Studies from the Rockefeller Institute for Medical Research Volume 3 (Paperback)

This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1916 edition. Excerpt: ...and filtered rapidly from the undissolved residue. 5 grams of the salt separated on cooling. It melted at 155-60, dissolved readily in water, and gave a pink color with sulphuric acid. 0.1779 gn. of substance required 5.15 cc. AgNO, Solution I. Calculated for CHMON, Br: Br = 22.49 per cent. Found: Br = 22.92 per cent. p-Methylphenoxyethylhexamethylenetetraminium Bromide.--The salt was obtained in the same way as the ortho isomer. Yield: 33 grams, containing chloroform of crystallization. After boiling with dry acetone, the salt melted at 1760. It was somewhat more readily soluble in water than the ortho isomer, and gave no color with sulphuric acid. 0.2071 gm. of substance required 5.8 cc. AgNO, Solution I. Calculated for C, sHaON4Br: Br = 22.49 per cent. Found: Br = 22.21 per cent. a-Naphthyl Bromoethyl Ether a-Naphthoxyethyl Bromide).--i This was prepared in the same way as jw-cresoxyethyl bromide. Yield: 11o grams, boiling at 154-6 at 0.8 mm., from 145 grams of ct-naphthol, 80 grams of 50 per cent aqueous sodium hydroxide in 250 cc. of absolute alcohol, and 500 grams of ethylene bromide. The boiling point was unchanged by a subsequent distillation. A few drops of the substance, on long standing in a freezing mixture, with occasional rubbing, yielded crystals which caused the solidification of the entire distillate. Recrystallized from ligroin with the aid of a freezing mixture, the ether forms transparent, hexagonal plates which melt at 250 (corrected) with slight preliminary softening. At room temperature it is sparingly soluble in methyl and ethyl alcohols, readily so in benzene, ether, and ligroin. It turns orange under sulphuric acid and dissolves with a greenish yellow color. 0.2253 gm, of substance gave 0.1657 gm. AgBr..