XPE (Ddb2) (Paperback)

High Quality Content by WIKIPEDIA articles! The XPE (DDB2) gene codes for a 1.8 kb mRNA with 10 exons and 9 introns. It will form a heterodimer with DDB1 to recognize the damage caused by UV-light. The defect in XPE causes a mild form of Xeroderma pigmentosum. Xeroderma pigmentosum, or XP, is an autosomal recessive genetic disorder of DNA repair in which the ability to repair damage caused by ultraviolet (UV) light is deficient.:574 In extreme cases all exposure to sunlight must be forbidden, no matter how small. Multiple basal cell carcinomas and other skin malignancies frequently occur at a young age in those with XP. In fact, metastatic malignant melanoma and squamous cell carcinoma are the two most common causes of death in XP victims. XP is roughly six times more common in Japanese people than in other groups.