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APC PROTECTNET 100BT/10BT/TR
Automatic voltage regulation for protection against brownouts and
APC Essential SurgeArrest 5 outlets 230V South Africa
Basic Protection Against Power Surges for Computers and Electronics
180 degree Rotating Cord Retainer
A 180-degree rotating cord with strain relief offers flexibility in positioning the SurgeArrest, and in routing the power cord.
Manual disconnect switch
Enables the surge supressor to be de-energized for service without disconnecting the protected load.
Right Angle Plug
Plug angle allows for equipment and furniture to be placed closer to the wall than with a standard power cord. Reduces cord stress too.
Transformer Block Spacing
Connect bulky transformer block plugs without covering up other outlets.
The initial identification of the Adenomatous polyposis coli (Apc) gene as the site of mutations in familial adenomatous polyposis (FA P) was described in 1992. A causal relationship between Apc mutations and intestinal tract tumours was confirmed three years later with the establishment of the Min mouse model. These mice are heterozygous for Apc and develop numerous intestinal tumours that mimic FA P. Subsequently, Apc has emerged as the most commonly mutated gene in colorectal cancer with reports varying between 50-80% of sporadic tumours carrying such mutations. The search for how mutations in Apc initiate and/or support progression of tumours in the intestinal tract has revealed that the Apc protein is a multifunctional participant in a diverse array of cellular functions. By collecting and assembling the chapters in this book, we aimed to provide an overview of the diverse functions performed by the Apc protein. As summarised in a short final chapter by Trainer, heterozygosity of Apc leads to a number of extracolonic manifestations that further support this emerging picture of the Apc protein as an active contributor to many different cellular functions. The first recognised function of Apc was its role in Wnt signalling. This function is one of the driving forces for how mutations in Apc ensure that cells remain proliferative. Many of the molecular details of this pathway have been discovered and are described in the first chapter by Kennell and Cadigan. The transcriptional changes that result from Apc mutations due to changes in the transcriptional contribution of -catenin are exacerbated by direct functions of Apc in the nucleus, which are discussed by Neufeld. The transcriptional changes induced by mutant Apc provide the background against which other cellular functions of Apc become particularly important in the digestive tract epithelium. Cell migration contributes significantly to the normal maintenance of this tissue, a
The M113 is the most widely used and versatile armoured vehicle in the world. Fielded in 1960 as a simple 'battlefield taxi', over 80,000 M113s would see service with 50 nations around the world and 55 years later, many thousands are still in use. In addition to its original role of transporting troops across the battlefield, specialized versions perform a multitude of other functions including command and control, fire support, anti-tank and anti-aircraft defence, and casualty evacuation. This new fully illustrated study examines the service record of the M113 from its initial fielding through to the end of the Vietnam War. It will also describe the many US, South Vietnamese, and Australian variants of the M113 used in the Vietnam War as well as information on tactics, unit tables of organization and equipment, and a selection of engagements in which the M113 played a decisive role.
Smart-UPS On-Line provides high density, true double-conversion
on-line power protection for servers, voice / data networks,
medical labs, and light industrial applications. Capable of
supporting loads from 1 to 20kVA in a rack/tower convertible form,
the Smart-UPS On-Line is available from 2U to 12U. Recent family
extensions at 15 and 20kVA enable support of power hungry blade
servers or heavily loaded equipment racks. When business-critical
systems require runtime in hours, not minutes, Smart-UPS On-Line
can be configured with matching battery packs to comply with
aggressive runtime demands. The included PowerChute management
software provides unattended graceful shutdown of network operating
systems. All models 5kVA and above include an integrated Network
Management Card for remote management (optional on models below 5
kVA). The Smart-UPS On-Line family provides customers with a
reliable source of uninterruptible power even in demanding power
environments, including very wide input voltage window, extremely
tight output voltage regulation, frequency regulation, internal
bypass, and input power factor correction.
This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis. The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers.
High Quality Content by WIKIPEDIA articles USNS Sgt. George D. Keathley, was a World War II United States cargo vessel that was used for troop transport and later converted to a survey vessel. She was laid down and launched as MS Alexander R. Niniger, Jr., then renamed MS Acorn Knot. She was put into US Army service as USAT Acorn Knot, then renamed USAT Sgt. George D. Keathley. She was transferred to the US Navy and became USNS Sgt. George D. Keathley (T-APC-117), but was later re-designated T-AGS-35. She was leased to the Republic of China, where she served as Chu Hwa (AGS-564). Both Nininger and Keathley were posthumous Medal of Honor recipients.
The initial identification of the Adenomatous polyposis eoli (Ape) gene as the site of mutations in familial adenomatous polyposis (FAP) was described in 1 1992. ,2 A causal relationship between Ape mutations and intestinal tract tumours was confirmed three years later with the establishment ofthe Min mouse model) These mice are heterozygous forApe and develop numerous intestinal tumours that mimic FAP. Subsequently, Ape has emerged as the most commonly mutated gene in colorectal cancerwith reports varying between 50-80% ofsporadic tumours car- rying such mutations. The search for how mutations in Ape initiate and/or support progression oftumours in the intestinal tract has revealed that the Ape protein is a multifunctionalparticipant in a diverse array ofcellular functions. By collecting and assembling the chapters inthisbook, we aimed toprovide an overview of the diverse functions performed by the Ape protein. As summarised in a short final chapter by Trainer,heterozygosityofApe leads to a number ofextracolonic manifestations that further support this emerging picture ofthe Ape protein as an active contributor to many different cellular functions. The first recognised function of Ape was its role in Wnt signalling. o This function is one of the driving forces for how mutations in Ape ensure that cells remain proliferative. Many of the molecular details of this pathway have been discovered and are described in the first chapter by Kennell and Cadigan.
APC International, Ltd.'s textbook on the principles and
applications of piezoelectric ceramics covers: general principles
of piezoelectricity and behavior of piezoelectric ceramic elements
fundamental mathematics of piezoelectricity traditional and
experimental applications for piezoelectric materials, and related
physical principles for each application: audible sound producers,
flow meters, fluid level sensors, motors, pumps, delay lines,
transformers, other apparatus introduction to single crystals,
composites, and other latest-generation piezoelectric materials
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